Anal cancer is very rare in the general population, but much more common in well defi ned, high-risk populations, including women with a previous cervical precancer, men who have sex with men (MSM), and individuals with HIV. Infection with carcinogenic human papillomavirus (HPV) has been increasingly recognised to cause anal cancer. In The Lancet Oncology, Dorothy Machalek and colleagues report...

AIMS To characterise further the proliferative compartment of the normal cervix and to document its alteration, if any, in the various grades of cervical intraepithelial neoplasia (CIN), particularly changes to the basal epithelial layer; to hypothesise as to the diagnostic and biological significance of any observed differences. METHOD Proliferative compartments from 86 cervical biopsy speci...

Transformed cells differ from normal cells in their pattern of heat shock protein expression. Here, we report differential expression of a Mr 70,000 heat shock protein (HSP7O) in squamous cell carcinomas of the uterine cervix compared to normal or premabignant uterine cervix. Expression of HSP7O was measured using a mouse mAb against HSP7O by an ELISA. A significant increase in the bevel of exp...

Introduction. Cervical canal polyps are a common disease in gynecological practice. In the vast majority of cases, cervical benign disease, but signs dysplasia and malignancy can be observed 0.1–10% cases. The doctor faces task getting rid polyp preventing its recurrence, which is not an easy task, since etiology pathogenesis development this completely clear. There opinion about connection occ...

Introduction. Lymphomas are malignant diseases of the lymphocyte lineage. There two basic types lymphoma: Hodgkin's lymphoma (HL), whose main characteristic is presence Reed-Sternberg cells, and non-Hodgkin's (NHL), which presents a heterogeneous group diseases, depending on growth rate course disease, they can be indolent (slow-growing) aggressive (fast-growing). Follicular (FL) most common fo...

OBJECTIVE Is Trichomonas vaginalis (TV) an inducing factor for the development of (pre-)cancerous lesions of the cervix? DESIGN Cross sectional study. SETTING Screening healthy Belgian women with low infection risk. SAMPLE 63,251 consecutive liquid based cervical samples. METHODS Real time quantitative PCR for presence of TV, 18 HPV types and Pap smear analysis of cytologic abnormalitie...

Previous studies have shown the involvement of the immune response in the progression of human uterine cervix cancer. The aim of this study was to determine the expression of Interleukin-2 (IL-2), IL-2 receptor (IL-2R) and Interleukin 10 (IL-10) in different grades of cervical intraepithelial neoplasias of the exocervix (CIN 1, 2 and 3), and its relationship with the serum cytokine profiles and...

OBJECTIVE An audit of outcomes of cervical cancer screening and prevention services for HIV-positive women in Cape Town, South Africa. DESIGN Retrospective review of clinic registers, patient records and pathology databases at three HIV primary health clinics and a tertiary colposcopy referral centre. SUBJECTS Women recently diagnosed with HIV at three primary health clinics between 2006 an...

OBJECTIVE The objective of the study was to evaluate the potential safety and effectiveness of tissue spectroscopy for the diagnosis of cervical cancer in a prospective multicenter study of women scheduled for colposcopy on the basis of an abnormal Pap test or other risk factor. MATERIALS AND METHODS Five hundred seventy-two women underwent spectroscopy of the cervix during their colposcopy v...

Blinded urinary assays for cyclic guanosine 3':5'-monophosphate (cGMP) and cyclic adenosine 3':5'-monophosphate (cAMP) were performed on 49 subjects with documented ab normal cervical cytology and 21 control subjects with normal cytology. A significant difference in the mean cGMP:cAMP ratios between the case and control groups was found. A significantly greater proportion of women with cytologi...