BACKGROUND We present the electrophilic synthesis of [18F]2β-carbomethoxy-3β-(4-fluoro)tropane [[18F]CFT] and the pharmacological specificity and selectivity of [18F]CFT for monoamine transporters in the brain and peripheral organs of rats. The human radiation dose is extrapolated from the animal data. METHODS [18F]CFT was synthesized by electrophilic fluorination of a stannylated precursor b...

BACKGROUND AND PURPOSE The empirical use of antibiotic therapy is widely accepted for patients with fever and neutropenia during cancer chemotherapy. The use of intravenous monotherapy with broad-spectrum antibiotics in patients at high risk for complications is an appropriate alternative. However, few data are available for pediatric patients. The aim of this study was to compare the efficacy ...

The DØ Level 2 (L2)trigger is a subsystem of the overall DØ trigger [1] which has the responsibility of reducing the event rate from 10 KHz to 1 KHz, while introducing less than 5% deadtime. The system is organized as a number of preprocessors and a global processor. Each preprocessor digests information from a single detector system and produces a condensed list of the objects. The global proc...

Decreased total testosterone (TT) is the recommended metric to identify age-related hypogonadism. However, average TT and the extent to which it varies by age, can vary substantially among different populations. Population-specific reference ranges are needed to understand normal versus abnormal TT levels. Therefore, the goal for this study was to describe androgen concentrations and their corr...

The aim of this work was to prepare a kit of Tc-ceftizoxime (Tc-CFT), with stability and biological activity preserved, able to identify a septic focus (E. coli) in the experimental infection model in rats. The preparation of the CFT kit involved the use of lyophilized solutions containing the antibiotic ceftizoxime and the sodium dithionite reducing agent (6.0 mg/mL). After lyophilization, the...

OBJECTIVES There are technical limitations for the currently available methods of measuring serum total and free testosterone in females. The study objectives were to evaluate the usefulness of serum total testosterone, sex hormone-binding globulin (SHBG), free androgen index (FAI), and calculated free testosterone (CFT) in the assessment of androgen status in women investigated for suspected h...

We present a new method to calculate the spectrum of (slow-roll) inflationary perturbations, inspired by the conjectured dS/CFT correspondence. We show how the standard result for the spectrum of inflationary perturbations can be obtained from deformed CFT correlators, whose behavior is determined by the Callan-Symanzik equation. We discuss the possible advantages of this approach and end with ...

The cerebral ganglia neurons of Aplysia californica are involved in the development and modulation of many behaviors. The medially located F cluster has been characterized using morphological, electrophysiological and biochemical techniques and contains at least three previously uncharacterized neuronal population. As the three subtypes are located in three distinct layers, they are designated ...

Background. Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia (MRSAB) is associated with significant morbidity and mortality. Vancomycin (VAN) is the drug of choice for MRSAB, optimization of VAN dosing is challenging in the setting of an elevated MIC (>1-2mcg/ml). Daptomycin (DAP) is an alternative for MRSAB, however DAP MICs tend to be elevated among patients with elevated VAN MIC...