Apolipoprotein E (apoE) is highly expressed in adipose tissue and adipocytes in which its expression is regulated by peroxisome proliferator-activated receptor (PPAR)-gamma agonists and tumor necrosis factor-alpha. There is, however, no information regarding a role for endogenous apoE in differentiated adipocyte function. In this report, we define a novel role for apoE in modulating adipocyte l...

Primary human hepatocytes are considered to be the "gold standard" cellular model for studying hepatic fatty acid and glucose metabolism; however, they come with limitations. Although the HepG2 cell line retains many of the primary hepatocyte metabolic functions they have a malignant origin and low rates of triglyceride secretion. The aim of this study was to investigate whether dimethyl sulfox...

The importance of insulin for the in vivo effects of growth hormone (GH) on lipid and lipoprotein metabolism was investigated by examining the effects of GH treatment of hypophysectomized (Hx) female rats with and without concomitant insulin treatment. Hypophysectomy-induced changes of HDL, apolipoprotein (apo)E, LDL, and apoB levels were normalized by GH treatment but not affected by insulin t...

Hepatic stellate cells store the majority of the liver's retinoid (vitamin A) reserves as retinyl esters in stellate cell lipid droplets. A study was conducted to explore the effects of differences in dietary retinoid and triglyceride intake on the composition of the stellate cell lipid droplets. Weanling rats were placed on one of five diets that differed in retinoid or triglyceride contents. ...

To test whether estrogen can modulate the cholesterolemic response to an Occidental diet, six healthy postmenopausal women were studied for 84 days while ingesting a solid food diet of constant composition high in cholesterol content (995 mg/d). In the middle of the study, estrogen (17 alpha-ethinyl estradiol, 1 microgram/kg per day) was administered orally. Ingestion of the diet for the initia...

the purpose of this study was to investigate the hypothesis weather the combination of lead acetate and deltamethrin can enhance avian toxic effects produced by lead exposure only. overall, 48 japanese quails, coturnix coturnix japonica (15 day old) were randomly divided into 4 experimental groups of 12 birds each and sex ratio of 1:1. experimental groups consisted of control japanese quails, b...

although there are many evidences regard to the relationship between serum thyroid hormones, cholesterol, triglyceride and lipoproteins in different animals, but there are limited references in dogs. the aim of this study was to determine the correlation between thyroid hormones and concentrations of serum lipid and lipoprotein profiles, and also to detect relationship between the measured para...

When injected into the rabbit 3 acidic azoproteins produced marked changes in the blood triglyceride levels. 4-Arsonophenylazoproteins, which were found to act similarly in 2 other mammalian species, produced a gross and prolonged hyperlipemia. 4-sulfono- and 4-carboxyphenylazoproteins in the rabbit produced an initial elevation and later lowering in blood triglyceride levels. The correlation b...