Heat shock proteins (HSP) convey both chaperoned propeptide and danger signal to dendritic cells (DC). However, few studies have compared the two activities. Using a murine inducible hsp70 secreted by cells distinct from those providing the tumor antigens, we showed that hsp70 exerts efficacious adjuvant effects toward DC cross-priming. Hsp70 induces DC maturation and phagocytosis of cellular d...

Purpose: Salmonella is a significant pathogen affecting wider range of animals and one the main causes diarroeal diseases leading to millions human cases globally. Pathogenicity islands (SPI) are imperative in invasion host cell pathogenesis within cell. It found that SPI from 1 5 present every serovars S. enterica these laterally acquired virulence regions.Research Method: This study investiga...

Protein aggregation and precipitation is associated with many debilitating diseases including Alzheimer's, Parkinson's, and light-chain amyloidosis. β-Casein, a member of the casein family, has been demonstrated to exhibit chaperone-like activity to protect protein form aggregation. Hofmeister salts (lyotropice series) are a class of ions which have an effect on the solubility and also the stab...

Epigenetic alterations, including DNA acetylation, hypermethylation and hypomethylation, and the associated transcriptional changes of the affected genes are central to the evolution and progression of various human cancers, including pancreatic cancer. Cancer-associated epigenetic alterations are attractive therapeutic targets because such epigenetic alterations, unlike genetic changes, are po...

Citronella grass (Cymbopogon nardus) is a plant containing many metabolite compounds which prevent and treat various diseases, one of cancer. Antioxidant found in citronella have been shown to improve the immune system by increasing cytokines. The activity changing homeostasis generates free radicals. Free radicals causing protein damage so that Heat Shock Protein-70 (HSP70) overexpressed. HSP7...