Subgroup and stratification analyses have been widely applied in genetic association studies to compare the effects of different factors or control for the effects of the confounding variables associated with a disease. However, studies have not systematically provided application standards and computing methods for stratification analyses. Based on the Mantel-Haenszel and Inverse-Variant appro...

the purpose of this investigation was directed to propose sensitive, accurate and reproducible methods of analysis that can be applied to determine distigmine bromide (dtb), cyclopentolate hydrochloride (cphc), diaveridine hydrochloride (dvhc) and tetrahydrozoline hydrochloride (thhc) drugs in pure form and pharmaceutical preparations via charge-transfer complex formation with 7,7,8,8-tetracyan...

tyrosinase is a multifunctional copper-containing enzyme. it can catalyze two distinct reactions of melanin synthesis and benzaldehyde derivatives, which are potential tyrosinase inhibitors.  to find the relationships between charge distributions of benzaldehyde and their pharmaceutical behavior, the present study aimed at investigating nuclear quadrupole coupling constants of quadrupolare nucl...

Several risk stratification instruments for postoperative delirium in older people have been developed because early interventions may prevent delirium. We investigated the performance and agreement of nine commonly used risk stratification instruments in an independent validation cohort of consecutive elective and emergency surgical patients aged ≥50 years with ≥1 risk factor for postoperative...

objective(s): iscomatrix vaccines have now been shown to induce strong antigen-specific cellular or humoral immune responses to a broad range of antigens of viral, bacterial, parasite or tumor. in the present study, we investigated the role of iscomatrix charge in induction of a th1 type of immune response and protection against leishmania major infection in balb/c mice.  materials and methods:...

the interaction between benzo-15-crown-5 (b15c5), dibenzo-18-crown-6 (db18c6), dibenzyl-daza-18crown-6 (dbzda18c6), n-phenyl-aza-15-crown-5 (npha15c5) and dibenzopyridine-18-crown-6 (dbpy18c6) with π-acceptor 2,3-dichloro-5,6-dicyanobenzoquinone (ddq) in chloroform solution was studied spectrophotometrically. the interaction of b15c5-ddq and db18c6-ddq caused the formation of 1:1 charge transfe...

background: this study assessed the clinical usefulness of the solid phantom, which may compensate for the disadvantages of the water phantom, by comparing the radiological doses between the two depending on their depths. materials and methods: the experimental equipment used was a linear accelerator for medical use, water phantom, solid phantom, farmer type ion chamber and electrometer. the di...

Bacteria may encounter a very wide variety of conditions in nature. These include changes in salinity, temperature, pH, and the presence of antibacterial molecules that have evolved either to kill them or impede their growth. In response, some bacteria have evolved modifications of their membrane lipids that improve their survival. Among these are amino acyl derivatives of phosphatidylglycerol ...