نتایج جستجو برای: chek2
تعداد نتایج: 669 فیلتر نتایج به سال:
Chemical inhibitors of the checkpoint kinases have shown promise in the treatment of cancer, yet their clinical utility may be limited by a lack of molecular biomarkers to identify specific patients most likely to respond to therapy. To this end, we screened 112 known tumor suppressor genes for synthetic lethal interactions with inhibitors of the CHEK1 and CHEK2 checkpoint kinases. We identifie...
BACKGROUND Hereditary cancers account for 5-10% of cancers. In this study BRCA1, BRCA2 and CHEK2*(1100delC) were analyzed for mutations in 91 HBOC/HBC/HOC families and early onset breast and early onset ovarian cancer cases. METHODS PCR-DHPLC was used for mutation screening followed by DNA sequencing for identification and confirmation of mutations. Kaplan-Meier survival probabilities were co...
Previous studies have shown that two rare variants, rs11571833 in BRCA2 and rs17879961 in CHEK2 were associated with lung cancer. However, the associations between these two variants and urinary tract cancers risk remain largely unexplored. We applied imputation of three genome-wide association studies published in the database of Genotypes and Phenotypes (dbGaP). Unconditional logistic regress...
Introduction. Breast cancer is the most common tumor localization in heritable TP53-related syndrome (hTP53rc), previously called «Li-Fraumeni syndrome». This characterized by occurrence of a hereditary mutation TP53 gene. We wanted to demonstrate relatively high incidence hTP53rc structure breast tumors, as well present correct algorithm for diagnosis TP53-associated Russian population. Aim. T...
So far, we have not performed genetic testing on moderate cancer risk, such as CHEK2 testing for breast cancer. We feel that this would lead to a large number of the population being positive and that it is unlikely that all carriers would be offered surveillance. Furthermore, the economic burden from surveillance for moderate risk may not be acceptable in a situation where patients who already...
Patients and Methods From 2008 to 2011, 2995 women, aged 40 to 65 years with no previous history of breast cancer were enrolled in a prospective screening trial consisting of two annual rounds of MRI, ultrasound and mammography. 356 women had a CHEK2 mutation, 458 women had a first-degree relative with breast cancer and 2269 women had neither risk factor. Subjects were followed for incident can...
Inherited factors contribute to the lifetime risk of prostate cancer. These factors include a positive family history of cancer and a mutation in one of several prostate cancer susceptibility genes, A number of genome-wide association studies (GWAS) have identified over a number of single nucleotide polymorphisms that have been confirmed to be associated with prostate cancer risk We evaluated w...
The CHEK2 gene encodes the CHK2 protein, which is kinase involved in DNA repair processes. By activating a lot of cell substrates, it can regulate the cell cycle, demonstrates suppressive effects, and participates in the senescence and apoptosis processes. Mutations in the CHEK2 gene are associated with increased risk of numerous cancers. The case described herein is that of a woman with a miss...
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