Chemotherapy (chemo) is the specific systematic treatment administered in oncological practice for malignant neoplasms in order to destroy chaotically dividing abnormal cells. Chemo is a part of anticancer treatment along with radiotherapy, immunotherapy and surgery. The drugs used in chemotherapeutic protocols cannot be purchased over the counter; they can be taken with prescription only. Canc...

In the present study, we demonstrated that the levels of DKK1 were decreased in serums and tissues of GC. DKK1 levels inversely correlated with tumor class, TNM stage, distant metastasis and lymph node metastasis of GC. GC patients with low DKK1 levels had a poor overall survival. DKK1 inhibited the proliferation of GC cells in vitro and in vivo. DKK1 also inhibited invasion, but enhanced chemo...

BACKGROUND The present study is an economic evaluation comparing transoral robotic surgery (TORS) to (chemo)radiotherapy for the management of early T-classification oropharyngeal cancer. METHODS A societal perspective was adopted. Treatment for TORS and (chemo)radiotherapy were modeled using decision analysis and recurrences were modeled over a 10 year horizon with a Markov model. Model para...

We present the case of a 9-year-old boy with a non-germinomatous germ cell tumor (NGGCT) in the pineal gland that exhibited a fulminant course following chemo- and radiotherapy. After the detection of the tiny cerebellar enhancing nodule at the end of chemo- and radiotherapy, tumor seeding progressed rapidly into the entire cisternal space. We herein report a rare case of NGGCT with fulminant c...

the noncommuting graph $nabla (g)$ of a group $g$ is asimple graph whose vertex set is the set of noncentral elements of$g$ and the edges of which are the ones connecting twononcommuting elements. we determine here, up to isomorphism, thestructure of any finite nonabeilan group $g$ whose noncommutinggraph is a split graph, that is, a graph whose vertex set can bepartitioned into two sets such t...

let $n,t_1,...,t_k$ be distinct positive integers. a toeplitz graph $g=(v, e)$ denoted by $t_n$ is a graph, where $v ={1,...,n}$ and $e= {(i,j) : |i-j| in {t_1,...,t_k}}$.in this paper, we present some results on decomposition of toeplitz graphs.

in this paper we define the removable cycle that, if $im$ is a class of graphs, $gin im$, the cycle $c$ in $g$ is called removable if $g-e(c)in im$. the removable cycles in eulerian graphs have been studied. we characterize eulerian graphs which contain two edge-disjoint removable cycles, and the necessary and sufficient conditions for eulerian graph to have removable cycles h...

BACKGROUND Addition of the anti-CD20 monoclonal antibody rituximab to chemotherapy (R-chemo) has been shown to improve response rates and progression-free survival in patients with indolent or mantle cell lymphoma. However, the impact of R-chemo on overall survival is unclear. We performed a comprehensive systematic review and meta-analysis to examine the efficacy of combined immunochemotherapy...

This study demonstrates the selective tumor targeting and the antitumor efficacy of the N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-bound mesochlorin e6 monoethylenediamine (Mce6) and HPMA copolymer-bound Adriamycin (ADR) in combination photodynamic therapy (PDT) and chemotherapy against human ovarian OVCAR-3 carcinoma xenografted in female athynmic mice. The concentrations of Mce6 and A...

The objective of this case report is to present a case of primary ovarian insufficiency in 17 year old, single girl, who had Acute Lymphocytic Leukemia (ALL) and was treated with chemo and radiotherapy, followed by bone marrow transplant from her HLA matched brother. The patient was treated at King Abdulaziz Medical City, Riyadh, Saudi Arabia. She was diagnosed with primary ovarian insufficienc...