BACKGROUND Squamocellular anal carcinoma is increasingly diagnosed in patients with risk factors. METHODS State-of-the-art imaging with magnetic resonance imaging (MRI) using phased-array coils and volumetric multidetector computed tomography (CT) provides detailed visualisation of anal disorders, identification and extent assessment of neoplastic tissue, detection and characterisation of nod...

The multidisciplinary approach to treating squamous cell carcinoma of the head and neck is complex and evolving. Chemotherapy is increasingly being incorporated into the treatment of squamous cell carcinoma of the head and neck. Previously, radiotherapy following surgery was the standard approach to the treatment of loco regionally advanced resectable disease. Data from randomized trials have c...

6000 (communication orale) Induction docetaxel platinum 5-FU (TPF) followed by cetuximab-radiotherapy (cetux-RT) versus concurrent chemo-radiotherapy (CT/RT) in patients with N2b/c-N3 non operated stage III-IV squamous cell cancer of the head and neck (SCCHN) : Results of the GORTEC 2007-02 phase III randomized trial. View abstract Abstract 6003 (communication orale) Cetuximab-radiotherapy vers...

cancer stem cells (cscs) have been defined as a unique subpopulation in tumors, endowed with the capacity to initiate tumor progression, maintain self-renewal as well as metastatic potential. recently, more evidence strongly indicates the existence of cscs in solid tumors of wide variety of organs such as breast, brain and stomach. recent studies suggest that a special subpopulation of gastric ...

Aims To analyse outcomes and patterns of failure in patients with oropharyngeal carcinoma (OPC) treated definitive volumetric modulated arc therapy omission contralateral high level II lymph nodes (HLII) retropharyngeal (RPLN) the uninvolved neck. Materials methods Patients OPC between January 2016 July 2019 were retrospectively identified. In absence neck disease, institutional protocols allow...

The onset of chemo- and/or radio-resistance in tumour cells is one of the main causes of failure of integrated treatment protocols combining intra-arterial administration of platinum derivatives and radiotherapy, and is associated with recurrent disease and/or distant metastases. In the present study, the expression of a series of markers of chemo- and/or radio-resistance was investigated in 21...

e15677 Background: Almost 30% of patients with pancreatic cancer present with locally advanced tumours in absence of distant metastasis. Because surgical resection is often contraindicated by vascular invasion, this disease has a dismal prognosis. The combination of gemcitabine with concurrent radiation therapy is a promising approach that is being investigated in patients' unresectable pancrea...