Cancer is a major cause of mortality in the modern world, with more than 10 million new cases every year. This outline is expected to rise in the next few decades since the majority (59%) of people diagnosed with cancer is aged over 65. In fact, around one in three people will be diagnosed with cancer throughout their lifetime (Siegel et al., 2012; Bosetti et al., 2013). The foundation of cance...

This poster details the discovery of several novel cascade reactions enabling the generation of arrays of pharmacologically relevant small molecules. As such, the synthetic routes are high in molecular complexity generating power and operationally friendly producing attractive compounds for inclusion in file enhancement strategies. Compound libraries and core chemotypes have been designed utili...