Although important advances have been made in curing childhood cancer in the last several decades, long-term survivors face considerable morbidity and mortality because of late effects from their initial anticancer therapy. By 30 years after treatment, the cumulative mortality from treatment-related medical illness actually exceeds that of mortality from cancer recurrence. Cardiovascular diseas...

The incidences of childhood cancers in Thailand between 1995 and 1997 were determined from cancer registrations collected at five locations around the kingdom and compared with similar analyses performed at cancer registries in Asia, Europe and the USA. The incidence in Thailand was found to be lower than in some Asian and Western countries. Between 1988-1994 and 1995-1997, the incidence of chi...

INTRODUCTION Childhood cancer is rare and comprises only 1% of all cancers. The current incidence of childhood cancer in Namibia, as in many other African countries, is not known. The aim of this research was to assess the paediatric cancer incidence between 2003-2010 at Windhoek Central Hospital, the only pediatric oncology-referring centre in Namibia and to compare with the previous calculate...

We considered whether there are discrete windows of vulnerability in the development of cancer and which time periods may be of the greatest importance. Cancer was considered broadly, including cancers in childhood as well as adult cancers that may have an in utero or childhood origin. We concluded that there was evidence from animal and epidemiologic studies for causal relationships for precon...

We have studied the incidence pattern of childhood cancers in Korea. Although the incidence of many tumors in Korea is similar to that in other countries, the incidence of acute myelogenous leukemia, non-Hodgkin's lymphoma and hepatoma is greater in Korean children. Yonsei Cancer Center commenced a study of multi-modality treatment of childhood cancers in July 1974. The most striking improvemen...

Advancements in cancer treatments have increased the number of survivors of childhood cancers. Endocrinopathies are common complications following cancer therapy and may occur decades later. The objective of the current review is to address the main endocrine abnormalities detected in childhood cancer survivors including disorders of the hypothalamic-pituitary axis, thyroid, puberty, gonads, bo...

BACKGROUND Because survival rates among childhood cancer patients are increasing, assessing the risk of second and subsequent malignant neoplasms (SMNs) is ever more important. Using the Childhood Cancer Survivor Study cohort, we identified the risk of SMNS: METHODS A retrospective cohort of 13 581 children diagnosed with common cancers before age 21 years and surviving at least 5 years was c...

Since the reports in 1956 and 1958 that in utero radiation was associated with an increased risk of leukemia and solid cancers during childhood, this issue has been debated. Many epidemiological studies have been performed. Evidence for a causal association derives almost entirely from case-control studies, whereas practically all cohort studies find no association, most notably the series of a...

Abstract Common pediatric malignancies often surprise clinicians with unusual presentations. In this narrative, we report two patients common childhood cancer having unique neuroophthalmic characteristics. the first case, have a child solid tumor presenting blindness without proptosis, while second case is of hematological malignancy unilateral proptosis visual impairment. The highlights that c...

BACKGROUND High birthweight is an established risk factor for childhood leukaemia. Its association with other childhood cancers is less clear, with studies hampered by low case numbers. METHODS We used two large independent datasets to explore risk associations between birthweight and all subtypes of childhood cancer. Data for 16 554 cases and 53 716 controls were obtained by linkage of birth...