نتایج جستجو برای: childhood seizure
تعداد نتایج: 181139 فیلتر نتایج به سال:
We report the identification of bang senseless (bss), a Drosophila melanogaster mutant exhibiting seizure-like behaviors, as an allele of the paralytic (para) voltage-gated Na(+) (Na(V)) channel gene. Mutants are more prone to seizure episodes than normal flies because of a lowered seizure threshold. The bss phenotypes are due to a missense mutation in a segment previously implicated in inactiv...
An observational study of all children with intractable epilepsy at the Paediatric Institute prescribed Lamotrigine as an add-on therapy between January 1994 and November 1998 was conducted. A total of 30 children were recruited. Three had adverse effects to the drug and it was withdrawn. Of the remaining 27, there were 20 boys and 7 girls, ranging from 2 to 17 years. Fifteen children had gener...
Epilepsy affects between 0.5% and 1% of the population and starts in childhood in two-thirds of patients. Approximately 30% of patients with epilepsy who are less than 18 years of age have medically refractory seizures [1, 2]. Seizures may adversely impact intellectual functioning [3-6] and therefore good seizure control is of critical importance. Compared with the mature brain, the impact of s...
UNLABELLED Convulsions triggered by fever are the most common type of seizures in childhood, and 20% to 30% of them have recurrence. The prophylactic treatment is still controversial, so we performed a systematic review to find out the effectiveness of continuous phenobarbital and intermittent diazepam compared to placebo for febrile seizure recurrence. METHOD Only randomized, double-blind, p...
Although chronic vagus nerve stimulation (VNS) is an established treatment for medically-intractable childhood epilepsy, there is considerable heterogeneity in seizure response and little data are available to pre-operatively identify patients who may benefit from treatment. Since the therapeutic effect of VNS may be mediated by afferent projections to the thalamus, we tested the hypothesis tha...
Early detection of seizures could reduce associated morbidity and mortality and improve the quality of life of patients with epilepsy. In this study, the aim was to investigate whether ictal tachycardia is present in focal and generalized epileptic seizures in children. We sought to predict in which type of seizures tachycardia can be identified before actual seizure onset. Electrocardiogram se...
objective febrile convulsions are prevalent in children aged between 9 months and 5 years, with an incidence of 2-5%. on the other hand, iron deficiency anemia is the most common hematologic disease of infancy and childhood with a period of incidence that coincides with the time of developing febrile convulsions. therefore, it is hypothesized that there is a possible association between these c...
BACKGROUND Seizure is one of the common causes of childhood hospitalization with significant mortality and morbidity. There is limited data regarding acute seizures episodes form the developing countries. Current study aims to find the common etiology of seizure and classify seizure types in various age groups presenting to tertiary center in Western Nepal. METHODS This was a hospital based r...
We report a double blinded cross-over study involving Flunarizine versus placebo in the treatment of refractory childhood epilepsy. The patients studied were between the ages of 2 and 18; and were having more than 4 seizures per month not responsive to regular anticonvulsant medications. Of the 34 patients treated, 8 had a 50% decrease in their seizures during the placebo phase, 5 had a 50% dec...
Seizure is the most common paediatric neurological disorder, with up to 10% of children having at least one attack of seizures during childhood. Despite the great expansion of seizure treatments in children in the recent years, many patients are refractory to medical treatment. The discovery of microRNAs (miRNAs) revolutionized the world of molecular biology. Extensive studies have suggested cr...
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