OBJECTIVE To evaluate the efficacy of Coenzyme Q10 (CoQ10) supplementation in the prevention of migraine in children using a placebo-controlled, double-blinded, crossover, add-on trial. BACKGROUND CoQ10 has been demonstrated to have efficacy in migraine prevention in adults but lacks pediatric research with more rigorous methodology. CoQ10 has been observed to be deficient in a significant nu...

Migraine constitutes a relatively common reason for pediatric emergency room visits. Given the paucity of randomized trials involving pediatric migraineurs in the emergency department setting compared with adults, recommendations for managing these children are largely extrapolated from adult migraine emergency room studies and trials involving outpatient home pediatric migraine therapy. We rev...

Childhood migraine can be the expression of an unconscious attempt of the small patient to show a discomfort which is denied through the defence of somatization. We considered a sample of 73 children, 39 males and 34 females suffering from migraine. We evaluated the presence of emotional disorders through diagnostic interviews consisting of one by one submission of the Anxiety Scale Questionnai...

BACKGROUND A recent Cochrane Review demonstrated the remarkable lack of reliable clinical trials of migraine treatments for children, especially for the two most prescribed preventative treatments in the UK, Propranolol and Pizotifen.Migraine trials in both children and adults have high placebo responder rates, e.g. of 23%, but for a trial's results to be generalisable "placebo responders" shou...

OBJECTIVE Determine relative frequency of recurrent headache (HA) types in children and adolescents referred to a pediatric neurologist. METHODS AND SUBJECTS STUDY DESIGN Prospective, sequential, and observational. SETTING Private practice Pediatric Neurology Clinic in a Canadian city (Winnipeg). Patients and data collection: Information on those referred with HA between September 1998 a...

AIM The aim of this study was to report a single-centre experience of flunarizine in childhood migraine with focus on safety and efficacy. METHOD We conducted a retrospective observational audit of 72 individuals (40 male, 32 female; mean age 13y; age range 1y 6mo-17y) at a tertiary paediatric neurology unit between 1998 and 2009. Children were included if they had a diagnosis of migraine and...

We conducted a descriptive study of children presenting with recurrent headaches to the general pediatric services of a tertiary-care, public hospital in northern India. This paper reports on the triggering factors of migraine in this population. 43 children, 3-18 year old (23 females, median age 10 years), presenting with recurrent headache from April, 2011 to January, 2012, were enrolled. His...

The International Classification of Headache Disorders lists several types of headaches [1]. Among primary headaches, migraine, tension-type headache and trigeminal autonomic cephalalgias are included. However, the distinction between migraine and tension-type headache, especially in children, is not always easy and the same subject can sometimes or periodically experience migraine and tension-...

OBJECTIVE To examine the incidence of headache symptoms consistent with migraine and tension-type headache (TTH) in children with anxiety disorders. METHOD Parents of children with anxiety disorders (n=27) and children without anxiety disorders (n=36) completed a headache questionnaire based on the International Classification of Headache Disorders (2nd edition) criteria. RESULTS Children w...

MTHFR gene variants C677T and A1298C seem to be related to an increased risk of migraine. Folates' metabolism could play a role in the pathophysiology of migraine. We supplemented 16 children with migraine, hyperhomocysteinemia, and MTHFR polymorphisms with folic acid and obtained a resolution/reduction of migraine attacks. Although the mechanism leading to these effects has been not made clear...