BACKGROUND Children with Down syndrome have unique immune profiles and increased leukemia susceptibility. METHODS Mothers of 158 children with Down syndrome diagnosed with acute leukemia at 0 to 19 years in 1997 to 2002 and 173 children with Down syndrome but no leukemia were interviewed. Associations were evaluated via multivariable unconditional logistic regression. RESULTS No association...

Children with Down syndrome have an increased risk for developing both acute myeloid as well as lymphoblastic leukemia. These leukemias differ in presenting characteristics and underlying biology when compared with leukemias occurring in non-Down syndrome children. Myeloid leukemia in children with Down syndrome is preceded by a preleukemic clone (transient leukemia or transient myeloproliferat...

recent studies have provided evidence that common genetic variations could account for a proportion of leukemia in adult or children. to evaluate the contribution of candidate gene association studies to the understanding of genetic susceptibility to acute lymphoblastic leukemia we conducted a systematic review from published studies. the polymorphisms of genes encoding carcinogen-metabolizing ...

We report bilateral proptosis as the unusual initial presentation of juvenile myelomonocytic leukemia in a Ugandan child. Juvenile was diagnosed with complete blood count and bone marrow aspiration biopsy. This is first description orbital involvement occurring setting leukemia, despite leukemic infiltration relatively common middle East, Asia, Africa. In general, simultaneous neoplastic both o...

Down syndrome [DS] is the most common chromosomal disorder in population manifested by intellectual disabilities of varying degrees, often accompanied disorders organ systems. Compared to children without DS, these have a greater risk developing malignancy such as acute leukemia. Leukemia blood cells and lymph nodes form cancer children. Its treatment with DS more complex compared this syndrome...

Diseases can be caused by consuming foods that do not have a balanced nutritional value, choosing the wrong diet, or food menu. Diet is also risk factor for cancer, such as leukemia. In outpatient pediatric polyclinic of Dr. Soetomo Hospital Surabaya, leukemia one ten most common diseases. This study aims to analyze relationship between family culture menu selection and incidence in children at...

Scurvy is a nondiscriminatory disease process resulting from nutritional deficiency of ascorbic acid (vitamin C). Identifying scurvy can be demanding due to the perceived rarity condition, and it become tricky diagnostic question given variety nonspecific symptoms, including skeletal other systems affected. Diffuse musculoskeletal pain in children with no specific cause usually fugue. Different...

Clinically significant myocardial infiltration by blast cells is a rare occurrence in acute leukemia. Heart failure rate children with hemato-oncological diseases unknown. Here we report clinical case of an 8-year-old female patient B-cell lymphoblastic leukemia as well heart that resolved during specific therapy for the cancer. The patient's parents gave consent to use their child's data, incl...

Background: Acute leukemias comprise a heterogeneous group of diseases characterized by rapid and uncontrolled clonal expansion of progenitor cells of the hematopoietic system. Immunophenotyping helps subclassify acute leukemias into subgroups with prognostic implications. Materials and Methods: This descriptive observational cross-sectional study was performed on 80 newly diagnosed cases of a...