During infection with Chlamydia trachomatis, CD8(+) T cells are primed, even though the bacteria remain confined to a host cell vacuole throughout their developmental cycle. Because CD8(+) T cells recognize antigens processed from cytosolic proteins, the Chlamydia antigens recognized by these CD8(+) T cells very likely have access to the host cell cytoplasm during infection. The identity of the...

objective: this study was conducted in order to assess the prevalence of different cervicovaginal infections during pregnancy. materials and methods: totally 110 healthy pregnant women with complaints of vaginal symptoms in their third trimester of pregnancy were checked for vaginal candidiasis, bacterial vaginosis, vaginal trichomoniasis, streptococcus β hemoliticus, gonorrhea, syphilis, and i...

PURPOSE Little is known about the susceptibility of posterior segment tissues, particularly the human retinal pigment epithelium (hRPE), to Chlamydia trachomatis. The purpose of the study was to investigate the possibility of infecting the hRPE with Chlamydia trachomatis, and to examine the infectivity of different Chlamydia trachomatis clinical isolates for hRPE cells and the hRPE cell respons...

background: chlamydia trachomatis is the etiology of most of sexually transmitted diseases. colonization of c. trachomatis in the genital tract during early gestation has been associated with preterm birth, and preterm premature rupture of the membranes. the role of c. trachomatis on spontaneous abortion has not yet been proved completely. the aim of this study was to evaluate the frequency of ...

results: in total, 8.5% of all subjects were positive (11% of symptomatic and 6% of asymptomatic men). statistical analysis revealed an association between condom usage as a variable and infection in asymptomatic group (p ≤ 0.05). conclusions: findings of this study show that chlamydial infection screening especially in males with urogenital symptoms is necessary (at least in tehran) and we rec...

BACKGROUND & OBJECTIVES Ocular infection with Chlamydia trachomatis is a major public health problem in densely populated countries like India. The true prevalence of such infections is uncertain due to insufficient data available from India. The aim of this study was to do a retrospective analysis of C. trachomatis eye infections in patients attending the outpatient department of Dr Rajendra P...

Congenitally athymic nude mice and their heterozygous counterparts were inoculated intravaginally with the chlamydial agent of mouse pneumonitis, a Chlamydia trachomatis biovar. Heterozygous mice resolved their infections in 20 days, whereas nude mice developed chronic infections which lasted at least 265 days and did not resolve within the time course of the experiments. Heterozygous mice prod...

Chlamydia trachomatis polymorphic membrane proteins (Pmps) may increase genital tract inflammation and play a role in virulence. Antibody levels for PmpA, PmpD, and PmpI, measured in densitometric units, were assessed among a pilot sample of 40 C. trachomatis-infected women with mild-to-moderate clinical PID. Women who expressed antibodies to PmpA were less likely to achieve pregnancy (40.0% ve...