A study was conducted to compare the efficacy of meditation with that of imipramine and chlordiazepoxide in the treatment of Generalized Anxiety Disorder. At the end of five weeks, meditation was found to be as effective as pharmacotherapy in controlling symptoms of anxiety. It was superior in altering trait anxiety (TMAS Scores). Meditation is an easy to learn and cost effective therapy. It ha...

The introduction of sustainable development concepts to analytical laboratories has recently gained interest, however, most conventional high-performance liquid chromatography methods do not consider either the effect of the used chemicals or the amount of produced waste on the environment. The aim of this work was to prove that conventional methods can be replaced by greener ones with the same...

Separate sub-populations of benzodiazepine receptors are involved in determining hippocampal theta frequency in freely moving rats. Systemic injection of the benzodiazepine chlordiazepoxide (CDP) reduced the frequency of theta elicited by stimulation of the brainstem reticular formation, and theta recorded during fixed interval (FI) bar pressing. Infusion of the benzodiazepine receptor antagoni...

Purified laccase from the soil ascomycete, Paraconiothyrium variabile was employed in the degradation of 7 benzodiazepine substances in the absence and presence of the enzyme mediators, 1-hydroxybenzotriazole (HBT), 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulphonate) (ABTS), 2,6-dimethoxyphenol (DMP), and vanillic acid (VA). In the absence of a laccase mediator, the original concentrations of 10...

Stonier, P.D., A.C. Parrott, and 1. Hindmarch: Clobazam in combination with nomifensine (HOE 8476): effects on mood, sleep, and psychomotor Performance relating to car-driving ability. Drug Dev. Res. S1:047-055, 1982. The effects of three dose regimens of HOE 8476, a combination of nomifensine (25 mg) and clobazam (7.5 mg), placebo, and a combination of amitriptyline (25 mg) and chlordiazepoxid...

ERSTAD, B. L. & COTOGNO,C. L. (1995) Management of alcohol withdrawal. American Journal of Health-System Pharmacy. 52. 697-709. HESSIONM. A.. VERMA.S. & MOHANBHAKTA,K. G. (1979) Dependence on chlormethiazole and effects of its withdrawal. Lancet, i. 953-954. KAIM.S. C.. KLETT.C. J. & ROTHFELD. B. (1969) Treatment of the acute alcohol withdrawal state: a comparison of four drugs. American Journa...

To determine if there is an increase in the risk of seizure activity when patients experience recurrent alcohol detoxification, the histories of 360 alcoholics who had at least two admissions for alcohol detoxification, between November 1987 and August 1992, were reviewed retrospectively. All subjects were treated with tapering doses of chlordiazepoxide as required, to control symptoms/signs of...