cholecystokinin

نتایج جستجو برای: cholecystokinin

تعداد نتایج: 3694 فیلتر نتایج به سال:

Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity.

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1990

J Hughes P Boden B Costall A Domeney E Kelly D C Horwell J C Hunter R D Pinnock G N Woodruff

PD134308 and PD135158 are potent and selective antagonists at the cholecystokinin type B (CCK-B) receptors with IC50 values of 1.6 nM and 3.5 nM, respectively, in the radioligand binding assay and Ke values of 7.82 and 12.9 nM, respectively, in their blocking action on CCK responses in the rat lateral hypothalamic slice. PD134308 and PD135158 produced potent anxiolytic effects in the mouse blac...

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Physiological role of cholecystokinin in meal-induced insulin secretion in conscious rats. Studies with L 364718, a specific inhibitor of CCK-receptor binding.

Journal: :Diabetes 1987

L Rossetti G I Shulman W S Zawalich

It has been suggested that the gut hormone cholecystokinin (CCK), by modulating insulin output from pancreatic beta-cells, plays an important role in the enteroinsular axis. To investigate this hypothesis, eight rats were studied on two different occasions: after injection of L 364718, a specific antagonist of CCK binding to its membrane receptor, and after vehicle injection. In both studies a ...

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Activation of cholecystokinin neurons in the dorsal pallium of the telencephalon is indispensable for the acquisition of chick imprinting behavior.

Journal: :Journal of neurochemistry 2007

Fumihiko Maekawa Tomoharu Nakamori Motoaki Uchimura Ken Fujiwara Toshihiko Yada Shinji Tsukahara Tomoyuki Kanamatsu Kohichi Tanaka Hiroko Ohki-Hamazaki

Chick imprinting behavior is a good model for the study of learning and memory. Imprinting object is recognized and processed in the visual wulst, and the memory is stored in the intermediate medial mesopallium in the dorsal pallium of the telencephalon. We identified chicken cholecystokinin (CCK)-expressing cells localized in these area. The number of CCK mRNA-positive cells increased in chick...

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