The characterization and subsequent availability of synthetic substance P has renewed interest in the role of this undecapeptide in central-nervous-system function (Mroz & Leeman, 1974). Biochemical and electrophysiological studies have demonstrated that substance P may function as an excitatory transmitter in primary sensory neurons terminating in the spinal cord (Otsuka & Konishi, 1975). In t...

Mycobacterium avium complex (MAC) is the most common non-tuberculous mycobacterium (NTM) and causes different types of pulmonary diseases. While genomic transcriptomic analysis 104 (M. 104) has been extensive, little known about proteomics M. 104. We utilized technology to analyze changes in whole proteome during exponential stationary growth phases. found 12 dys-regulated proteins; up-regulate...

Endogenous choline acetyltransferase (ChAT) activity and high affinity (HA) 3H-choline uptake can be assayed specifically and used to quantify cholinergic neuronal mechanisms. In general, arteries at the base of the brain in the cat and rabbit were distinguished by high and in the dog by lower ChAT activity and 3H-choline levels of uptake. There was a linear relationship between the mean values...

Changes of choline acetyltransferase (ChAT) activity in the hippocampus and the basal ganglia were studied in rats treated i.p. with L-carnitine (CRT) and 7-methoxytacrine (7-MEOTA) (i.m.) separately or 3-days treated with L-carnitine and then with one administration of 7-MEOTA. Both compounds increased ChAT activity when administered separately. 3-day treatment of CRT followed by administratio...