AIM The aim of prenatal diagnostics is to provide information of the genetic abnormalities of the fetus early enough for the termination of pregnancy to be possible. Chromosomal abnormalities can be detected in an unborn child through the use of cytogenetic, molecular- cytogenetic and molecular methods. In between them, central spot is still occupied by cytogenetic methods. In cases where use o...

Prostate cancer incidence is steadily increasing in Western industrialized countries where it has become the most common male malignancy and second most common cause of cancer death among men. Despite efforts to understand the mechanisms of prostate cancer development and progression, the reasons for the disease remain unclear. Although recurrent DNA copy number aberrations in prostate cancer h...

By B. MODAN, B. PADEH, H. KALLNER, E. Axsr IN, D. MEYTES, P. CZERNIAK, B. RAMOT, J. PINKHAS AND M. MODAN T HE RELATIVELY HICH RISK of developing leukemia in the course of polycythemia vera ( PV ) , and the presence of both specific and nonspecific chromosomal aberrations in patients with myeloprohferative disorders,25 led us to undertake a prospective follow-up study of patients with PV. In thi...

C HROMOSOMAL CHANGES are frequently encountered in a variety of neoplastic conditions and are of great interest to both the pathologist and geneticist.2#{176} Chromosomal studies have had a profound impact on medical genetics. Further investigations are required, however, in order to elucidate the relationship between neoplasia and chromosome patterns. These studies should help to clarify the r...

Modern radiation cytogenetics has adopted the principle that DNA molecule as an essential biological substrate is the most important target of ionizing radiation. This action may result in delicate lesions of the hereditary material that may be manifested in the form of structural chromosomal aberrations. This study present results of years of cytogenetic studies of chromosomal aberrations in i...

In the present investigation the antimutagenic effects of Phyllanthus fruit extract (PFE) has been evaluated against cyclophosphamide induced genotoxicity in bone marrow cells of mice. The administration of Phyllanthus fruit extract at various doses i.e. 170, 340 and 680 mg /kg . When treated individually did not induce chromosomal aberrations in somatic cells of mice(24 hr). A single Intra per...

Agricultural soils are increasingly becoming sinks for wide number of hazardous contaminants which ultimately result in pollution. Plant bioassays, because of their sensitivity and affordability, have been recommended as first-tier assays which enable the detection of contaminants. The present study involves genotoxicity of four soil samples collected from different regions of Amritsar employin...

Aberrant recombination between T-cell receptor genes and oncogenes gives rise to chromosomal translocations that are genetic hallmarks in several subsets of human T-cell acute lymphoblastic leukemias. The V(D)J recombination machinery has been shown to play a role in the formation of these T-cell receptor translocations. Other, non-T-cell receptor chromosomal aberrations, such as SIL-TAL1 delet...

Epilepsy is among the most common findings associated with chromosome aberrations, particularly those involving autosomal chromosome imbalances. Most chromosome aberrations can be associated with different seizure types, but there are a few aberrations featuring specific seizure and electroencephalographic (EEG) patterns. The analysis of electro-clinical patterns associated with chromosomal abe...

The process of karyotype evolution in Cervidae from a common ancestor (2n = 70, FN = 70) has been marked by complex chromosomal rearrangements. This ancestral karyotype has been retained by the current species Mazama gouazoubira (Fischer 1814), for which a chromosomal polymorphism (Robertsonian translocations and the presence of B chromosomes) has been described, presumably caused by a chromoso...