I would like to take issue with Rithidech et al., authors of the paper entitled "Lack of genomic instability in mice at low doses" [1] who claim to have shown that their results on the measurement of late occurring chromosome aberrations after irradiation of SCID mice with X-rays show that lower doses (0.05 Gy) do not induce genomic instability. Their earlier work at higher doses (0.1 and 1.0 G...

Fluorescence In situ hybridization (FISH) is a technique that can be used for the analysis of genomic aberrations in tumor cells. The resolution level of FISH is by far better than chromosome banding which is also widely used for the study of chromosome aberrations in cancer. In addition to the improved resolution FISH allows for the analysis of genomic aberrations not only on metaphase chromos...