The Caenorhabditis elegans genome contains three rac-like genes, ced-10, mig-2, and rac-2. We report that ced-10, mig-2 and rac-2 act redundantly in axon pathfinding: inactivating one gene had little effect, but inactivating two or more genes perturbed both axon outgrowth and guidance. mig-2 and ced-10 also have redundant functions in some cell migrations. By contrast, ced-10 is uniquely requir...

Temporal control of programmed cell death is necessary to ensure that cells die at only the right time during animal development. How such temporal regulation is achieved remains poorly understood. In some Caenorhabditis elegans somatic cells, transcription of the egl-1/BH3-only gene promotes cell-specific death. The EGL-1 protein inhibits the CED-9/Bcl-2 protein, resulting in the release of th...

Adolescents among the urban and rural poor have a high incidence of chronic energy deficiency (CED) and anemia, more so in girls than in boys. Adolescent pregnancies (15-19 years) contribute to 19% of total fertility in India and record the highest maternal mortality rates. Besides maternal age, lack of education, low socio-economic status, maternal undernutrition and limited access to maternal...

Convection-enhanced delivery (CED) circumvents the blood-brain barrier by delivering agents directly into the tumor and surrounding parenchyma. CED can achieve large volumes of distribution by continuous positive-pressure infusion. Although promising as an effective drug delivery method in concept, the administration of therapeutic agents via CED is not without challenges. Limitations of distri...

The continuous increase in the complexity of current designs generates logic circuits that are less immune to soft errors. As the soft error rate increases, Concurrent Error Detection (CED) techniques are becoming ever more essential. A plethora of research efforts have been expended in developing CED techniques that provide high levels of reliability [1, 2, 3]. Yet, the high overhead associate...

The potential of the central nervous system (CNS) to regenerate is regulated by a complex interaction of neuronal intrinsic and extrinsic factors that remain poorly understood. Significant research has been dedicated to identifying these factors to facilitate design of therapies that will treat the functional impairment associated with CNS injuries. Over the last decade, the development of in v...

The new N, Z = 14(16) shell stabilization and the N = 20 shell quenching in Mg are supposed to be dominated by the monopole part of the nucleon-nucleon residual interaction. Disregarding the different neutron binding energy an isospin symmetric scenario is expected for the N = 16-20 mirror region [1] and can be verified by experiments along the light Ca (Z = 20) isotopes by studying the Coulomb...

The ICE/CED-3 family of proteases has been implicated in playing a fundamental role in programmed cell death. Bcl-2 protein represses a number of apoptotic death programs, but the biochemical mechanism of its action is not known. We investigated the activation of ICE/CED-3 proteases induced by three apoptotic stimuli (staurosporine, ceramide, and serum withdrawal) in the neuronal cell line GT1-...

OBJECTIVE The protein Hwp1, expressed on the pathogenic phase of Candida albicans, presents sequence analogy with the gluten protein gliadin and is also a substrate for transglutaminase. This had led to the suggestion that C. albicans infection (CI) may be a triggering factor for Celiac disease (CeD) onset. We investigated cross-immune reactivity between CeD and CI. METHODS Serum IgG levels a...

more efficient electrical grids, and advance clean energy research and development (R&D). The new action plan also places a greater emphasis on energy efficiency. Accomplishments to date under the CED include: (1) completing the final phase of the Weyburn-Midale Carbon Dioxide Monitoring and Storage Project, which focuses on best practices for the safe and permanent storage of carbon dioxide (C...