Introduction. Extramedullary sites of leukemic proliferation, harboring an adverse outcome, are rare and usually found in the blastic phase chronic myeloid leukemia. We report a case newly diagnosed patient with leukemia phase, infiltration right ovary on disease presentation. Case report. The presented abdominal pain, leukocytosis, anemia. A peripheral blood smear indicated leukemia, cytoreduc...

Background: Priapism is defined as a prolonged erection of the penis lasting over 6 hours in absence sexual stimulation. divided into two types, Low-Flow (ischemic priapism) and High-Flow (trauma). This case study aims to evaluate penile gangrene priapism sequele due Chronic Myeloid Leukemia (CML) first report Indonesia.Case Presentation: A 45-years old male patient admitted at Muara Teweh hosp...

3. Talpaz M, Spitzer G, Hittelman W, Kantarjian H, Gutterman J. Changes in granulocyte-monocyte colonyforming cells among leukocyte-interferon-treated chronic myelogenous leukemia patients. Exp Hematol 1986; 14:668-71. 4. Santucci MA, Soligo D, Pileri S, Zuffa E, Testoni N, Tura S. Interferon-alpha effects on stromal compartment of normal and chronic myeloid leukemia hematopoiesis. Leuk Lymphom...

Chronic myeloid leukemia is a myeloproliferative disorder that has three distinguished phases: chronic, accelerated, and blastic. In extremely rare cases, the blast phase can affect the central nervous system without concomitant bone marrow involvement. We report the case of a patient with chronic myeloid leukemia who, despite having achieved complete cytogenetic remission in the bone marrow fo...

The frequency of sister chromatid exchange (SCE) was analyzed in bone marrow cells of 16 patients with chronic myeloid leukemia. We have compared the SCE frequency in these patients, in both chronic and blastic phases of the disease, to that of normal individuals. The frequency of SCE in blastic-phase chronic myeloid leukemia patients (mean, 1.86/cell) was significantly lower than that in chron...

Chronic myeloid leukemia (CML) is caused by the reciprocal translocation t(9;22)(q34;q11), resulting in BCR-ABL1 fusion gene. tyrosine kinase inhibitors (TKIs) improve overall survival patients with chronic phase CML (CML-CP). Approximately half of who achieve a durable deep molecular response can sustained treatment-free remission (TFR) after TKI discontinuation; thus TFR now therapeutic goal ...

introduction: heterochromatin consists of dna sequences that are not transcribed, and are repeated in short tandem at heterochromatic regions of chromosomes 1, 9, 16 as well as the distal part of long arm of chromosome y. slightly large tandem repeats at the centromeres of human chromosomes are also considered as heterochromatin regions. the main aim of the present study is to evaluate the hete...

INTRODUCTION In developing countries, there is commonly a lack of population-based cancer registries or underreporting, thus not recognizing the true dimensions of the problem. AIM To describe the age and sex frequencies of the major subtypes of leukemias in two hospitals of reference in the metropolitan area of Mexico City. MATERIAL AND METHODS This is a descriptive and retrospective study...

Since the era of tyrosine kinase inhibitor (TKI) therapy, there has been an increase in median survival chronic myeloid leukemia. Nevertheless, nowadays were several cases leukemia that are resistant to first-line TKIs, so second-line TKIs introduced. Assessment therapeutic response was performed using a complete peripheral blood examination, bone marrow aspiration cytogenetic and quantitative ...

Abstract Background Leukemia is one of the most common tumors in children and it is divided up into two main groups acute and chronic leukemia. The acute leukemia is more prevalent than chronic in children. Generally acute type is included acute lymphoid leukemia (ALL) and acute myeloid leukemia (AML). In this study, patients with leukemia who were admitted in Talghani hospital of Gorgan were...