tracheomegaly or tracheobronchomegaly is a rare syndrome which is characterized by dramatic dilatation of the trachea and the major bronchi. this syndorme is usually associated with chronic respiratory infection and airway obstruction. in this paper, a case with tracheomegaly and bronchiectasis was scrutinized.

BACKGROUND We aimed to evaluate and define the general clinical applicability and impact of pulmonary radioaerosol mucociliary clearance (PRMC) on the work up of patients suspected of having primary ciliary dyskinesia (PCD). In addition, we wanted to evaluate the accuracy of the reference values used in the PRMC test. METHODS Measurement of PRMC after inhalation of (99m)Tc-albumin colloid aer...

MUCOCILIARY CLEARANCE plays a crucial host-defense role in both the upper and lower airways, providing protection from a wide variety of airborne hazards including allergens, pathogens, and environmental toxins. Proper function of the mucociliary clearance system depends on the structure and function of the cilia as well as the composition of the airway surface liquid layer. The mucus component...

Abstract In this study heat transfer effects on cilia induced mucus flow in human airways is presented. The elliptic wave pattern of tips produces metachronal which enables the transportation highly viscous with nonzero inertial forces. Upper Convective Maxwell model considered as mucus. governing partial differential equations are transformed from fixed frame to by using Galilean transformatio...

Metachronal beating of cilia of epithelial surfaces of most respiratory airways moves the overlying mucous layer in a caudal direction. The molecular mechanisms controlling ciliary beat remain largely unknown. Calcium, an element in its cationic form, is ubiquitous in biological functions and its concentration is critical for ciliary beating. Calmodulin, a calciumbinding protein which regulates...

Mucociliary clearance and fluid transport along epithelial surfaces are carried out by multiciliated cells (MCCs). Recently, human mutations in Cyclin O (CCNO) were linked to severe airway disease. Here, we show that Ccno expression is restricted to MCCs and the genetic deletion of Ccno in mouse leads to reduced numbers of multiple motile cilia and characteristic phenotypes of MCC dysfunction i...

Airway mucus is part of the lung's native immune function that traps particulates and microorganisms, enabling their clearance from the lung by ciliary transport and cough. Mucus hypersecretion and chronic productive cough are the features of the chronic bronchitis and chronic obstructive pulmonary disease (COPD). Overproduction and hypersecretion by goblet cells and the decreased elimination o...