نتایج جستجو برای: cleaved caspase 3
تعداد نتایج: 1833060 فیلتر نتایج به سال:
Caspases are proteolytic enzymes that are essential for apoptosis. Understanding the many discrete and interacting signaling pathways mediated by caspases requires the identification of the natural substrate repertoire for each caspase of interest. Using an amplification-based protein selection technique called mRNA display, we developed a high-throughput screen platform for caspase family memb...
The current study was designed to investigate the effect of ginsenoside Rb1 (Rb1) on apoptosis induced by hypoxia and oxidative stress in a retinal ganglion cell line (RGC-5). The underlying mechanism was also investigated. RGC-5 cells were pretreated with 10 µmol/l Rb1 for 24 h and exposed to 400 µmol/l cobalt chloride (CoCl2) for 48 h or 600 µmol/l H2O2 for 24 h. The percentage of cells activ...
20(S)-protopanaxadiol (PPD) is an active natural product which transformed from protopanaxadiol-type ginsenosides. The present study was conducted to evaluate the effects of PPD on myocardial ischemia/reperfusion (I/R) injury in a rat model. (20mg/kg) or positive-control drug Diltiazem (10mg/kg) administered daily for 7 days before left anterior descending I/R operation. After 2-hour reperfusio...
Proprioception from masticatory apparatus and periodontal ligaments comes through the trigeminal mesencephalic nucleus (Vmes). We evaluated effects of tooth loss on neurodegeneration Vmes motor (Vmo). Bilateral maxillary molars 2-month-old C57BL/6J mice were extracted under anesthesia. Neural projections to periodontium confirmed by injecting Fluoro-Gold (FG) retrogradely into extraction socket...
A-kinase-anchoring protein 149 (AKAP149) is a member of a structurally diverse, though functionally similar anchoring protein family and is localized to the outer membrane of mitochondria and in the endoplasmic reticulum-nuclear envelope network. AKAP149 plays an important role in controlling the subcellular localization and temporal specificity of protein phosphorylation and mRNA metabolism by...
OBJECTIVE To investigate the effects of resveratrol on autophagy in the chronically diabetic nephropathy and to study the effects of the different expression of microRNAs after resveratrol (RSV) treated in db/db mice (diabetic mice). MATERIALS AND METHODS Db/m (non- diabetic) and db/db mice were randomly divided into intra gastric RSV treatment group or control group. Renal tissues were prepa...
Total flavones of Selaginella uncinata (Desv.) spring has inhibitory effects on cancer progression. The study aims to analyze the total breast cell tumor properties and possible mechanism. MDA-MB-231 cells were treated with or transfected anti-microRNA-negative control anti-microRNA-1269. In addition, microRNA-negative microRNA-1269 mimics-transfected exposed uncinata. Cell proliferation apopto...
Microvascular complications eventually affect nearly all patients with diabetes. Advanced glycation end-products (AGEs) resulting from hyperglycemia are a complex and heterogeneous group of compounds that accumulate in the plasma and tissues in diabetic patients. They are responsible for both endothelial dysfunction and diabetic vasculopathy. The aim of this study was to investigate the cytotox...
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