OBJECTIVES The objective of this study is to evaluate the effects of a soy drink with a high concentration of isoflavones (ViveSoy®) on climacteric symptoms. METHODS An open-label, controlled, crossover clinical trial was conducted in 147 peri- and postmenopausal women. Eligible women were recruited from 13 Spanish health centers and randomly assigned to one of the two sequence groups (contro...

Life changes have been associated with illness onset. The Social Readjustment Rating Scale (SRRS) records numerical perceptions of the meaning of life events while the Schedule of Recent Experience (SRE) records the frequency of occurrence of life events. Data on these two instruments from 19 studies done in this laboratory have been surveyed and analyzed. They reveal significant variability am...

AIM Depressive disorders and symptoms are common among middle-aged women. The effects of hormones on depression remain unclear. This review aims to clarify the nature of depressive disorders during the menopause transition as well as their links with climacteric syndrome, sexuality, cardiovascular risk and cognitive function. MATERIAL AND METHODS The recent literature on depressive disorders ...

OBJECTIVE To assess attitudes and beliefs about the menopausal transition in a population of peri- and postmenopausal women, and if these attitudes differed before and after publication of studies on risks and benefits with hormone therapy (HT). MATERIALS AND METHODS In 1999 and 2003 all women aged 53 and 54 years in the community of Linköping, Sweden, were sent a questionnaire about use of H...

Focusing more closely on the question of climacteric symptoms and by listing these symptoms in an order of occur­ rence, one finds that nearly 90% of the effects of sexual hormones are of an extragenital nature and that, therefore, the use of the expression “sexual” to describe these hormones is too much of a restriction in terms of a functional analysis (fig 1). The term “extragenital target o...

To investigate the clinical effects of EH0202, a Japanese herbal supplement, on the menopausal symptoms and physical status of peri- and post-menopausal women. Thirty-two post-menopausal women (53.0+/-5.1 years) presented with menopausal complaints were enrolled in the clinical study. Patients were administered an herbal supplement, EH0202 (6 g/day for 6 months), and were assessed for improveme...

OBJECTIVE To evaluate the effectiveness of a phytotherapeutic intervention comprising a combination of Hypericum perforatum (St. John's wort) and Vitex agnus-castus (Chaste tree/berry) in the management of menopausal symptoms. DESIGN A double-blind, randomized, placebo-controlled, parallel trial was performed over 16 weeks in 100 eligible late-perimenopausal or postmenopausal women experienci...