introduction: hcl is a rare malignant condition that is curable if diagnosed early. hcl can present with reduced blood cells and splenomegaly which maybe misdiagnosed with other conditions. the aim of the present study was to determine the frequency of early clinical and laboratory findings as well as the response rate of patients to the standard treatment regimen of cladribine. methods: the st...

background : cancer stem cells are a subgroup of tumor cells that have the capability for self-renewal and differentiation and are characterized by multiple markers. several studies have been conducted to identify these cells in colorectal cancer, including stem cell marker cd24. this study has evaluatedtheassociation of cd24 expression with clinicopathologic features and survival in an immunoh...

Cutaneous manifestation of COVID 19 in children has not yet been reviewed systematically. Hence, this review gives the clinicians a future direction to be vigilant for skin presentations during pandemics. The Pubmed database used literature search with keywords 19, children, and different combinations. Articles published English cases age one month 18 years were eligible. outcome included varie...

CONTEXT Intraductal carcinoma of the prostate (IDC-P) is a distinct clinicopathologic entity, characterized by an expansile proliferation of secretory cells within prostatic ducts and acini that demonstrate marked architectural and cytologic atypia. Intraductal carcinoma of the prostate is strongly associated with high-grade and high-volume, invasive prostate cancer and a poorer prognosis than ...

BACKGROUND The CpG island methylator phenotype (CIMP), which is characterized by simultaneous methylation of the CpG islands of multiple genes, has been recognized as one of the important mechanisms in gastrointestinal carcinogenesis. METHODS Methylation of the 5 methylated-in-tumors (MINT) loci and 12 tumor-related genes in 78 primary gastric carcinomas was examined using combined bisulfite-...

Autoimmune pancreatitis (AIP) is a rare form of chronic pancreatitis that is characterized by lymphoplasmacytic infiltrate, storiform fibrosis, obliterative phlebitis, and increased IgG4(+) plasma cells. Serum IgG4 levels usually are elevated. Patients with AIP frequently have disease affecting other organs or sites; these tissues show similar histologic changes, including increased IgG4(+) pla...

A clinicopathologic case of Hughes-Stovin syndrome with pulmonary eosinophilic angiitis and focal proliferative extracapillary glomerulonephritis is reported.

PURPOSE This study was designed to compare the clinicopathologic findings of an endoscopic polypectomy for malignant polyps with subsequent surgery and to evaluate the appropriateness of the pathologic finding criterion of the resection margin as an indicator for surgery in cases of malignant colorectal polyps. METHODS We examined the clinicopathologic characteristics, complications and progn...