In this editorial we review the data on the use of multi-dose ROM (Rifampicin, Ofloxacin and Minocycline) as an alternative treatment to WHO-MDT (World Health Organisation multidrug therapy) comprising rifampicin, clofazimine and dapsone. There is now sufficient evidence to warrant a large trial of this new regimen. The adverse effects of the current MDT regimen are probably under-estimated and...

Aplastic anaemia associated with multidrug therapy (dapsone, rifampicin and clofazimine) in a patient with lepromatous leprosy ISABELA M. B. GOULART, ANA CLÁUDIA S. REIS, TATIANA M. N. DE REZENDE, AÉRCIO S. BORGES, MARCELO S. FERREIRA & SÉRGIO A. NISHIOKA State Reference Center for Sanitary Dermatology and Leprosy, Clinical Hospital, Faculty of Medicine, Federal University of Uberlândia, Minas ...

Although dapsone (DDS) continues to b~ the standard treatment for the majority of leprosy patients, alternative drugs are required fbr the therapy of the ever increasing number of patients developing sulphone resistance . Because a high proportion of patients with active lepromatous leprosy in Malaysia now have DDS resistance (mouse foot-pad proven) , they have been used in many of our long-ter...

BACKGROUND We investigated the effectiveness of long-term antibiotic treatment in patients with Crohn's disease. METHODS We performed a systematic review and meta-analysis of randomized clinical trials. Data sources were Medline (from 1966 through June 2009), EMBASE (from 1980 through June 2009), Cochrane Central Register of Controlled Trials (issue 3, 2009), and references from relevant publ...

BackgroundMultidrug-resistant tuberculosis (MDR-TB) patients have been suffering long, ineffective, and toxic treatment until short-course injectable-free regimens emerged. However, the new WHO-recommended might be less feasible in real-world setting. Here, we evaluated two optimized all-oral China.MethodsFrom April 2019 to August 2020, conducted a prospective nonrandomized controlled trial con...