BACKGROUND Heart failure (HF) is associated with inflammation characterized by the formation of the inflammasome, which triggers maturation of inflammatory cytokines. Apoptosis-associated speck-like protein with a caspase recruitment domain (ASC), a vital component of the inflammasome, is controlled through epigenetic modification, which may be a candidate pathway for worsening HF. This study e...

The weight is one of the main issues of Data Envelopment Analysis (DEA), and relevant theoretical research indicates that many DEA mathematical models include redundant restraints on weight, resulting in underestimated efficiency, pseudo inefficiency, and difficulty in representing specific Input/Output relationships. This study proposes a context-dependent DEA-R model to address shortcomings r...

the genus eremostachys (lamiaceae), consists of about 60 species which 15 species of eremostachys grow wildly in the north-west of iran. the rhizomes and roots of e. laciniata have traditionally been used as a local analgesic and for the treatment of rheumatic diseases and pain in the feet. this experiment was conducted in the north-west of iran in 2012-2013, to evaluate morphological diversity...

In this study the effects of plant growth regulators including; GA3 (0 and 50 mg/l) and ethephon (0 and 500 mg/l) were studied on the quality properties of two grape cultivars (Perlette and Yaghuti). At the harvest time, some physicochemical characteristics such as fruit cluster weight, fruit diameter, length, volume and L/D ratio, flesh firmness, fresh weight, TA, pH, TSS and fruit color were ...

SUMMARY Affinity propagation (AP) clustering has recently gained increasing popularity in bioinformatics. AP clustering has the advantage that it allows for determining typical cluster members, the so-called exemplars. We provide an R implementation of this promising new clustering technique to account for the ubiquity of R in bioinformatics. This article introduces the package and presents an ...

We study shock statistics in the scalar conservation law ∂tu+∂xf(u) = 0, x ∈ R, t > 0, with a convex flux f and random initial data. We show that a large class of random initial data (Markov processes with downward jumps and derivatives of Lévy processes with downward jumps) is preserved by the entropy solution to the conservation law and we derive kinetic equations that describe the evolution ...

Atazanavir (ATV) is one of the latest protease inhibitors (PI) approved for the treatment of HIV infection. The drug has a relatively long-life (~7 h) and large inhibitory quotient which allows once daily administration. It is generally well tolerated and the main side effect is hyperbilirubinemia, since ATV inhibits the hepatic uridin-glucoronyl-transferase. A signature mutation at the proteas...

This paper addresses the problem of circuit clustering for delay minimization, subject to area capacity constraints. We use the general delay model, for which only heuristic solutions were known. We present an optimum polynomial-time algorithm for combinational circuits under this model. Our algorithm can be generalized to solve the problem under any monotone clustering constraint.