In the past few years, a renowned interest in interplay between immune system and central nervous systems (CNS) has sparked wealth of new experimental studies. Two recent publications Science shed light on “resident” cell populations CNS their functions homeostasis pathological status, with potential implications understanding disease mechanisms designing “intelligent” therapies.

Introduction: Orofacial clefts are among the most common congenital anomalies. Patients presenting with orofacial clefts often require surgery or other complex procedures. A cleft lip or palate can be a single anomaly or a part of multiple congenital anomalies. The reported prevalence of cleft disease and associated anomalies varies widely across the literature, and is dependent on the diagnost...

In the 1960s North Atlantic sea surface temperatures (SST) cooled rapidly. The magnitude of the cooling was largest in the North Atlantic subpolar gyre (SPG), and was coincident with a rapid freshening of the SPG. Here we analyze hindcasts of the 1960s North Atlantic cooling made with the UK Met Office’s decadal prediction system (DePreSys), which is initialised using observations. It is shown ...

Energy information systems (real-time acquisition, analysis, and presentation of information from energy end-uses) in commercial buildings have demonstrated value as tools for improving energy efficiency and thermal comfort. These improvements include characterization through benchmarking, identification of retrofit opportunities, anomaly detection to inform retrocommissioning, and feedback to ...

vascular variations and the accidental cutting of veins and arteries potentially create problems during surgery and medical treatment. the surgeon's awareness of a vascular variation in the kidneys is essential during renal surgery and transplantation, color doppler imaging, gonadal surgery and in the presence of an abdominal aortic aneurism. this awareness can improve the patient's r...

pregnancy in the rudimentary horn of uterus is rare. uterine rupture is a rare obstetrical catastrophe that occurs before 20 weeks’ gestation in 70% of unicornate uterus cases. a 24-year-old primigravida woman was referred to our hospital due to failed induction-in-17th-weeks-of-her-pregnancy. fetal-death was confirmed on abdominal ultrasound. examination under-anaesthesia revealed -pregnancy-i...

ADAM metalloprotease-disintegrins share a common modular structure of functional domains for proteolytic, cell adhesion, and signaling interactions. The metalloprotease domain of oughly half of the known ADAMs contain an intact consensus metzincin catalytic site, and they are thus thought to function as active metalloproteases. The types of interactions mediated by ADAMs are expressly conspicu...