Thirty-eight adults with acute lymphocytic leukemia (ALL), 24 previously untreated and 14 previously treated, were entered into a study in which sequential, moderate-dose methotrexate and asparaginase were added to vincristine and dexamethasone (MOAD) for remission induction therapy. Eighteen of 24 previously untreated patients (75%) and 11 of 4 previously treated patients (79%) achieved a comp...

Isolated central nervous system (CNS) relapse of non-Hodgkin lymphoma (NHL) is very rare. We report a five-year-old boy with T-cell lymphoblastic lymphoma (T-LBL), who developed CNS relapse under treatment when the primary tumor was in complete remission. The patient presented initially with persistent cough and an anterior mediastinal mass and had no bone marrow or CNS involvement at diagnosis...

BACKGROUND AND OBJECTIVES Visceral leishmaniasis (VL) is a common complication in AIDS patients living in Leishmania-endemic areas. Although antiretroviral therapy has changed the clinical course of HIV infection and its associated illnesses, the prevention of VL relapses remains a challenge for the care of HIV and Leishmania co-infected patients. This work is a systematic review of previous st...

A 42-year-old female was diagnosed with acute promyelocytic leukemia (APL) with a translocation of chromosomes 15 and 17 involving the PML and RARA genes. On presentation she met criteria for low-risk disease on the basis of platelet count (50 10/L) and WBC count (0.8 10/L). The patient achieved a complete molecular remission after induction chemotherapy with all-trans-retinoic acid (ATRA) and ...

BackgroundThere is rising concern on the impact of new strategies, such as high-dose chemotherapy (HDC) and immunotherapy, pattern relapse in high-risk neuroblastoma (HR-NBL). Our aim to evaluate incidence identify risk factors for first recurrence central nervous system (CNS) HR-NBL.Patients methodsData from patients with stage 4V HR-NBL included February 2002 June 2015 prospective trial Europ...

Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosis in children. While current treatment has greatly improved survival rates, relapse occurs in 15-20% of patients. Signs and symptoms are similar to those found at initial presentation. However, in some patients, relapse can occur in the central nervous system (CNS), even if they did not have previous CNS involvement. Many case...

abnormalities of the thyroid gland are among the most frequent endocrine complications observed in childhood cancer survivors. we report an 11 years old girl who developed central hypothyroidism and acth deficiency during the chemotherapy for cns relapse of acute lymphoblastic leukemia before receiving radiotherapy. keywords: thyroid gland, hypothyroidism, chemotherapy, acute lymphoblastic leuk...

BACKGROUND The addition of rituximab to CHOP (R-CHOP; CHOP, cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy improves outcome in patients with diffuse large B-cell lymphoma (DLBCL). We evaluated the risk of central nervous system (CNS) relapse in the R-CHOP in a population-based cohort of patients with DLBCL. METHODS Patients with DLBCL diagnosed from 1 September 1999 ...