A recent study (Nusrat, A., Chen, J. A., Foley, C. S., Liang, T. W., Tom, J., Cromwell, M., Quan, C., and Mrsny, R. J. (2000) J. Biol. Chem. 275, 29816-29822) suggested that phosphatidylinositol 3-kinase (PI 3-kinase) may interact with occludin; however, there exists no evidence of direct interaction of PI 3-kinase with the tight junctions. Activation of PI 3-kinase by oxidative stress and its ...

Unlike most bacteria, Streptococcus pneumoniae (pneumococcus) has two evolutionarily distinct ABC transporters (Pst1 and Pst2) for inorganic phosphate (Pi) uptake. The genes encoding a two-component regulator (PnpRS) are located immediately upstream of the pst1 operon. Both the pst1 and pst2 operons encode putative PhoU-family regulators (PhoU1 and PhoU2) at their ends. This study addresses why...

Insulin treatment of Chinese hamster ovary (CHO) cells expressing high levels of the insulin receptor (CHO-IR) was found to markedly activate (10-20-fold) transcription of the luciferase reporter gene (Luc) driven by the serum response element (SRE) of the c-fos promoter. SRE-Luc expression was also strongly activated by co-transfection with expression plasmids encoding for either v-Ras or v-Ra...

—Frequent itemset mining has emerged as a fundamental problem in data mining and plays an important role in many data mining tasks, such as association analysis, classification, etc. In the framework of frequent itemset mining, the results are itemsets that are frequent in the whole database. However, in some applications, such recommendation systems and social networks, people are more interes...

for a ring endomorphism $alpha$ and an $alpha$-derivation $delta$, we introduce a concept, so called skew $pi$-armendariz ring, that is a generalization of both $pi$-armendariz rings, and $(alpha,delta)$-compatible skew armendariz rings. we first observe the basic properties of skew $pi$-armendariz rings, and extend the class of skew $pi$-armendariz rings through various ring extensions. we nex...

Previous studies have found that some phosphate (Pi) starvation inducible transporter genes are downregulated and arbuscular mycorrhizal (AM) inducible Pi transporter genes are upregulated in maize roots associated with the fungus Glomus intraradices. However, little is known about the functional diversity of different AM fungal species in influencing the expression of Pi transporters in maize ...

Morbidity and mortality from co-morbid hepatitis C (HCV) infection in HIV co-infected patients are increasing; hence, the management of hepatitis co-infection in HIV is now one of the most important clinical challenges. Therefore, the development of direct acting antivirals (DAAs) for treatment of HCV has been eagerly awaited to hopefully improve HCV treatment outcome in co-infected individuals...

Front Cover: In article number 2100079 by Kailiang Ren and co-workers, a MoS2-g-PMMA/PI (MPP, PI is polyimide) nanocomposite consisting of thin layer poly(methyl methacrylate) coated 2D MoS2 nanosheets reported. The energy density MPP-3% (3% MoS2) reaches 8.6 J cm−3. Furthermore, the highest 3.92 cm−3 at 150 °C, which 47.9% higher than that film.

OBJECTIVE Hyperbilirubinaemia (HB) is common in HIV and hepatitis C virus (HIV-HCV) co-infected patients and poses a unique challenge in management as it may be due to medications such as the protease inhibitors (PIs) or to hepatic dysfunction. There are no data on the relationship of HB to liver histology and PI use in this population. Clinicians caring for these patients are faced with the di...