BACKGROUND Acute coagulopathy after traumatic brain injury (TBI) involves a complex multifactorial hemostatic response that is poorly characterized. OBJECTIVES To examine early posttraumatic alterations in coagulofibrinolytic, endothelial, and inflammatory blood biomarkers in relation to sympathetic nervous system (SNS) activation and 6-month patient outcomes, using multivariate partial least...

PURPOSE The purpose of this study was to investigate the role of low-dose recombinant factor VIIa (rFVIIa) (20 μg/kg) in reversing coagulopathy in patients with isolated traumatic brain injury (TBI). MATERIALS AND METHODS Patients with isolated TBI and coagulopathy at admission were enrolled prospectively from January 2010 to December 2011. The patients were divided into 2 groups: the rFVIIa ...

Traumatic-induced coagulopathy (TIC) is a hemostatic disorder that is associated with significant bleeding, transfusion requirements, morbidity and mortality. A disorder similar or analogous to TIC was reported around 70 years ago in patients with shock, hemorrhage, burns, cardiac arrest or undergoing major surgery, and the condition was referred to as a "severe bleeding tendency," "defibrinati...

Burn injury is traditionally referred to as a common triggering cause of acute coagulopathy, ranging from subclinical activation of coagulation to fulminant overt Disseminated Intravascular Coagulation (DIC). Coagulopathy associated with burn injury was well recognized as early as the 1970s.1,2 Coagulopathy in burn patients is considered to be driven by an endothelial injury, release of tissue ...

Introduction: Trauma-induced coagulopathy (TIC) is a form of unique to trauma patients and associated with increased mortality. The complexity incomplete understanding TIC have resulted in controversies regarding optimum management. This review aims summarise the pathophysiology appraise established emerging advances management TIC. Methods: narrative based on literature search (MEDLINE databas...

Russell’s viper and hump-nosed are deadly venomous Viperidae snakes in Sri Lanka. Both these vipers widely distributed all climatic zones of the island. causes systemic envenoming such as coagulopathy, neuroparalysis acute kidney injury (AKI) whilst frequently local rarely AKI coagulopathy. These two may cause atypical syndromes like thrombotic microangiopathy (TMA) hemolytic uremic syndrome (H...

Heyde syndrome is a triad of aortic stenosis, an acquired coagulopathy and anaemia due to bleeding from intestinal angiodysplasia. The evidence that aortic stenosis is the root cause of this coagulopathy is compelling. Resolution of anaemia usually follows aortic valve replacement. This article discusses studies linking aortic stenosis with other conditions in the triad as well as diagnosis and...

Consumption coagulopathy and microangiopathic hemolytic anemia occurred as a complication of insertion of an axillofemoral, preclotted dacron graft. Treatment with heparin followed by dipyridamole and aspirin normalized the hematologic and coagulation abnormalities over a two month period. The mechanism of consumption coagulopathy associated with prosthetic grafts is discussed and a possible ro...

•Ovarian cancer, particularly clear cell carcinoma, creates a hypercoagulable state.•This state can predispose to non-bacterial thrombotic endocarditis (NBTE).•NBTE can embolize and cause widespread arterial infarction.•NBTE is sometimes associated with a treatment refractory disseminated coagulopathy.•Surgical removal of the primary mass can sometimes reverse the coagulopathy.