Two recent papers, one from the Staley laboratory (Koodathingal and colleagues) and the other from the Cheng laboratory (Tseng and colleagues), show that the RNA-dependent ATPase Prp16, which is required for the second step of splicing, acts to reject slowly splicing pre-mRNAs immediately before the first catalytic reaction in pre-mRNA splicing. The results answer long-investigated questions ab...

Well As Methodological Rigor Compared with other study designs, well-done randomized trials provide the most valid estimate of the benefits of health interventions because they minimize bias. Systematic reviews of randomized trials identify all studies that have addressed a particular question, and metaanalyses combine the results by using methods that minimize bias (1). Many consider systemati...

Documentary linguistics is new and distinctive enough that some linguists other participants in academic reviews may be uncertain about how to assess its outputs. We recommend specific strategies for assessing documentary linguistic scholarship review contexts, based on a brief description of the field benefit colleagues areas.