Background: The refolding of proteins from inclusion bodies is affected by several factors, including solubilization of inclusion bodies by denaturants, removal of the denaturant, and assistance of refolding by small molecule additives. Objectives: The purpose of this study was optimization of recombinant human interferon-b purification in order to achieve higher efficiency, yield, and a produ...

We apply the alternating direction method of multipliers (ADMM) optimization algorithm to implicit time integration of elastic bodies, and show that the resulting method closely relates to the recently proposed projective dynamics algorithm. However, as ADMM is a general-purpose optimization algorithm applicable to a broad range of objective functions, it permits the use of nonlinear constituti...

This paper presents a general approach for designing and animating complex deformable models with implicit surfaces. Implicit surfaces are introduced as an extra layer coating any kind of structure that moves and deforms over time. Offering a compact definition of a smooth surface around an object, they provide an efficient collision detection mechanism. The implicit layer deforms in order to g...

Consider a particle moving freely on the torus and colliding elastically with some xed convex bodies. This model is called a periodic Lorentz gas, or a Sinai billiard. It is a Hamiltonian system with a smooth invariant measure, whose ergodic and statistical properties have been well investigated. Now let the particle be subjected to a small external force. This new system is not likely to have ...

Graphs of pairwise incidences between collections of rigid bodies occur in many practical applications and give rise to large algebraic systems for which all solutions have to be found. Such pairwise incidences have explicit, simple and rational parametrizations that, in principle, allow us to partially resolve these systems and arrive at a reduced, parametrized system in terms of the rational ...

Symbiotic stars are thought to show distinct X-ray emission from the accreting object and from the colliding winds of the two stars. I show that the colliding wind component is unnecessary. Instead, the spectra can be interpreted as emission only from the compact object that is strongly absorbed by the partially-ionised wind of the red giant. There remains no evidence of any X-ray emission from...