BACKGROUND Pancreatic neuroendocrine tumors (PNETs) are a group of rare tumors. Chromogranin A (CgA) was considered as the most practical and useful serum tumor marker in PNET patients. But peripheral blood levels of CgA are not routinely tested in Chinese patients with PNETs. This study was to assess the diagnostic value of CgA in Chinese patients with PNETs especially in patients with insulin...

Comprehensive geriatric assessment (CGA) is a process that consists of a multidimensional data-search and a process of analyzing and linking patient characteristics creating an individualized intervention-plan, carried out by a multidisciplinary team. In general, the positive health care effects of CGA are established, but in oncology both CGA and the presence of geriatric syndromes still have ...

Background: Tumour marker measurement gives clinicians useful information for the follow-up and management of patients with neuroendocrine tumours (NETs). The currently used tumour markers for NETs are neuron-speci¢c enolase (NSE) and chromogranin A (CgA). The clinical accuracy of these biomarkers depends on histotype and disease extent. CgA is thought to be the optimal marker for most NETs, as...

We calculate phase diagrams of charged colloidal spheres (valency Z and radius a) in a 1:1 electrolyte from multicentered nonlinear Poisson-Boltzmann theory. Our theory takes into account charge renormalization of the colloidal interactions and volume terms due to many-body effects. For valencies as small as Z = 1 and as large as 10(4) we find a gas-liquid spinodal instability in the colloid-sa...

The acidic protein chromogranin A (CgA) is the precursor of several regulatory peptides generated by specific proteolytic processes. Human recombinant CgA NH(2)-terminal fragment STA-CgA(1-78) (hrSTA-CgA(1-78)), containing vasostatin-1 (CgA(1-76)) domain, exerts a negative inotropic effect and counteracts the beta-adrenergic positive inotropic effect on the rat heart. We hypothesized an involve...

At equilibrium, colloidal particles in a subcritical liquid suspension are surrounded by a drying layer if the colloid has solvophobic interaction. Using Brownian dynamics computer simulations, we investigate the nonequilibrium response of this layer to a strong external driving force. We find that the driven colloidal particle dresses itself with more particles than in the equilibrium drying l...

BACKGROUND Chromogranin A (CgA) in plasma (P-CgA), a neuroendocrine marker of sympathetic stress, has been shown to predict mortality in medical intensive care. We hypothesized that the magnitude of CgA release would reflect stress load, and thereby injury severity in burn intensive care patients. METHODS Fifty-one consecutive patients with a burn area exceeding 10% were included. P-CgA was m...

Chlorogenic acids (CGA) are the main phenolic compounds in coffee and coffee has one of the highest concentrations of CGA of all plant constituents. In this study, the levels of CGA in certain coffee (Arabica Jimma (ArJM), Arabica Nekemit (ArNK), Arabica Sidamo (ArSD), Arabica Jimma (ArJM) raw, and Arabica Jimma (ArJM) Husk) brands found in Ethiopia were determined using High Performance Liquid...

The large dense-core secretory granule is an organelle in neuroendocrine/endocrine cells, where prohormones and proneuropeptides are stored, processed, and secreted in a regulated manner. Here we present evidence that chromogranin A (CgA), one of the most abundant acidic glycoproteins ubiquitously present in neuroendocrine/endocrine cells, regulates dense-core secretory granule biogenesis. Spec...

PURPOSE We investigated the clinical significance of chromogranin A (CgA) expression as a neuroendocrine (NE) marker during prostate cancer (PCa) progression, especially as a potential predictor of chemotherapeutic response in castration-resistant PCa (CRPC) patients based on immunohistochemical findings. MATERIALS AND METHODS Sixteen CRPC patients who underwent combination (docetaxel/estramu...