نتایج جستجو برای: colon delivery
تعداد نتایج: 278536 فیلتر نتایج به سال:
The gastrointestinal tract is a complex niche and the main port of entry of many pathogens that trigger a wide range of diseases like inflammatory bowel disease (IBD) and colon cancer. Antibodies are effective for treating such diseases, but a system capable of local delivery at the site of the pathology, thus avoiding systemic side effects, is not yet available. Here we report a novel recombin...
Recently, therapeutic proteins have been used to combat life-threatening diseases. To date, oral routes developed deliver proteins. Since the proteolytic degradation in upper gastrointestinal tract frequently occurs, we need a formulation and strategy protect protein colon. In this research, solid lipid nanoparticles (SLNs) were prepared eight formulae for colon-targeted delivery with various g...
There has been an ample interest in delivery of therapeutic molecules using live cells. Oral delivery has been stipulated as best way to deliver live cells to humans for therapy. Colon, in particular, is a part of gastrointestinal (GI) tract that has been proposed to be an oral targeted site. The main objective of these oral therapy procedures is to deliver live cells not only to treat diseases...
To overcome the limitations of the conventionally used methods for evaluation of orally administered colon-targeted delivery systems, a novel dissolution method using probiotics has been recently reported. In the present study, universal suitability of this medium composed of five different probiotics is established. Different delivery systems - mini tablets, liquisolid compacts, and microspher...
Gurpreet Kaur Ranbaxy Research Labs, Gurgaon, India Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala-147002, India Tel: 919814724622 Fax +91-(0175)-3046255 Email: [email protected] Abstract The present study was designed to formulate colon release tablets of fluticasone by employing cross linked chitosan (CH) and carboxymethyl guar gum (CMG) interpolymer comp...
Article history: Received on: 10/12/2012 Revised on: 29/12/2012 Accepted on: 15/01/2013 Available online: 28/01/2013 The aim of the present work was to develop and evaluate colon specific sustained release tablet using levetiracetam (LEV), microbially degradable polymeric carrier (pectin), coating material and matrix forming polymers. The colon targeted tablet was prepared by wet granulation te...
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