INTRODUCTION Ogilvie's syndrome describes the phenomenon of an acute colonic pseudo-obstruction without a mechanical cause. It is rare but has been reported to occur after Caesarean section. It can lead to bowel perforation or ischaemia. CASE PRESENTATION A healthy, 28-year-old Caucasian woman presented 2 weeks past her expected date of delivery for her first pregnancy. She underwent an uncom...

A double layer-coated colon-specific drug delivery system (DL-CDDS) was developed, which consisted of chitosan (CTN) based polymeric subcoating of the core tablet containing citric acid for microclimate acidification, followed by an enteric coating. The polymeric composition ratio of Eudragit E100 and ethyl cellulose and amount of subcoating were optimized using a two-level factorial design met...

Pectin fragments have powerful anti-metastatic properties but the molecular structure of the active component(s) is still unknown. Pectin hydrogels are used to encapsulate drugs for oral drug delivery. This polysaccharide is not digested in the upper intestinal tract but its degradation in the colon releases oligomers with potential bioactivity. Here we tested the release of pectin fragments in...

Although oral drug delivery is the preferred administration route and has been used for centuries, modern discovery development pipelines challenge conventional formulation approaches highlight insufficient mechanistic understanding of processes critical to absorption. This review presents opinion UNGAP scientists on four key themes across absorption landscape: (1) specific patient populations,...

Ulcerative colitis (UC) is a chronic, immunologically-mediated disorder which affects the gastrointestinal tract. This disease is characterized by inflammation of the colonic or rectal mucosa, leading to rectal bleeding, diarrhea, and abdominal pain. UC, along with Crohn’s disease, is referred to as inflammatory bowel disease. The specific cause of this disease is unknown, but research has sugg...

Colonic diverticula are outpouchings of mucosa and submucosa through the large intestine wall. Inverted colonic can be confused with adenoma. It is important to differentiate them. Here we report two cases inverted that seem like adenomas.

BACKGROUND Megachannel is a newly developed colonic access system allowing rapid and multiple passes of the colonoscope to the right side of the colon. OBJECTIVE The aim of this study was to evaluate the safety and clinical feasibility of placing a 100 cm Megachannel prototype in the right side of the colon. SETTING Six centers, international, both surgeons and gastroenterologists performin...