following failure of systemic chemotherapy, transarterial chemoembolization (tace) is an available method to control unresectable liver metastases from colorectal carcinoma (crc). the aim of present study was to evaluate the efficacy of chemoembolization for inoperable metastatic liver lesions from crc. forty-five crc patients with liver metastases resistant to systemic chemotherapy were enroll...

colorectal cancer is the second leading cause of cancer death worldwide. through risk assessment of malignancy in polyps, screening programs can achieve the best results. this study aimed to determine the association between the grade of dysplasia and the location of colorectal polyps. 240 colorectal adenomatous polyps which were referred to department of pathology at rasoul-e-akram hospital be...

background: the association between adenomatous polyps and malignancy has an important role in patient screening and follow up after polypectomy. due to less attraction towards the segmental resection, colonoscopic evaluation of malignancy has found its utmost importance role. polyp size and morphology have dictated the potential of malignancy in prior studies, however, in recent decade some au...

colorectal cancer is one of the most prevalent cancers in the world. it's survival expectancy depends on the time of diagnosis, stage and grade of the tumor, and general condition of the patient. survival expectancy of this type of cancer reveals the quality of diagnostic and therapeutic services in the community. to improve and standardize the treatment modalities in this field, much rese...

malakoplakia is a rare disease with undefined etiology that has been almost exclusively reported in urology and pathology journals. we are presenting a case of colonic malakoplakia in an i8-year old young man who was referred to us with a four-year history of intermittent rectorrhagia. the pathological examination of the endoscopically resected specimen revealed pathognomonic features of malako...

introduction: colo-rectal cancer has 10% prevalence, among all of the cancer proportionally and also it is the third common cancer in the both sexes. two recently introduced active drugs in the treatment of advanced colorectal cancer (acc) are irinotecan and oxaliplatin. the combinations of oxaliplatin (oxa) or irinotecan (iri) with 5fu-lv have been accepted as standard treatment for metastatic...

abstract: methylenetetrahydrofolate reductase (mthfr) is a key enzyme regulating folate metabolism, which affects dna methylation and synthesis. one of the most important polymorphisms identified in the mthfr gene is c677t. mthfr activity is lowered in individuals with 677tt genotype. using pyrosequencing, we analyzed the mthfr genotypes in 118 colorectal cancer patients and 189 normal matched ...

this study has examined the relationship between the xpd lys 751 gln polymorphism and colorectal cancer in 88 patients and their 88 age and sex-matched controls. genomic dna from peripheral whole blood was extracted using standard method to determine the genotype of subjects with rflp-pcr analysis. although this study shows cancer patients harbor more heterozygous genotype (xpd lys 751 gln) (or...

background:the present study compared the differences between survivals of patients with colorectal cancer according to their ethnicity adjusted for other predictors of survival. methods: in this prospective cohort study patients were followed up from definite diagnosis of colorectal cancer to death. totally, 2431 person-year follow-ups were undertaken for 1127 colorectal cancer patients once e...