background and aims. changes in the balance of sexual hormones during pregnancy decrease gingival crevicular fluid levels of interleukin-6 and the resistance of gingival tissue against inflammations. hormonal contraceptives are agents that are based on the effects of gestational hormones and simulate a state of pregnancy; therefore, they prevent ovulation. this study evaluates the effect of the...

Combined oral contraceptives, oral hormone replacement therapy and thrombophilias are recognised risk factors for venous thromboembolism in women. The objective of this study was to assess the risk of thromboembolism among women with thrombophilia who are taking oral contraceptives or hormone replacement therapy, conducting a systematic review and metaanalysis. Of 201 studies identified, only n...

BACKGROUND Adequate counselling on contraceptive methods can help users choose the most appropriate method. The aim of this study was to assess the effects of structured counselling provided by gynaecologists on selection of a combined hormonal contraception method. METHODS Women aged 18-40 years (n = 1871) who were considering the use of a combined hormonal contraception method (pill, transd...

OBJECTIVES A new method for the quantitative determination of 17alpha-ethinylestradiol-17beta (EE2) in serum is presented here based on the principle of isotope dilution mass spectrometry (IDMS) with [13C]EE2 as internal standard. The technique was used to determine the concentration profiles of EE2 in the serum of female subjects who had taken oral contraceptives with different progestin compo...

INTRODUCTION Oral contraceptives, mainly combined monophasic pills, are widely used by young women who expect their physicians to prescribe them safe drugs which will not harm their health and which will simplify their life. Numerous epidemiologic studies have been performed to determine the relation between oral contraceptive use and the development of neoplasms. BREAST CANCER An increased i...