نتایج جستجو برای: complement dependent lymphocytotoxicity cdc

تعداد نتایج: 759890  

Journal: :International journal of cancer 2004
Cornelis F M Sier Kyra A Gelderman Frans A Prins Arko Gorter

Metastases from renal cell carcinomas (RCC) are resistant to radiation and chemotherapy but are relatively immunogenic. We have investigated the possibility to eliminate human RCC micrometastases using MAb G250. G250 penetrates human micrometastases completely in a spheroid model and induces complement deposition rapidly on the outmost cell layers. However, complement dependent cytotoxicity (CD...

2012
Jeong-Won Hong Woon-Dong Cho Kwon Pyo Hong So-Seul Kim Seung-Myoung Son Seok-Joong Yun Ho-Chang Lee Sang-Soon Yoon Hyung-Geun Song

BACKGROUND Therapeutic approaches using monoclonal antibodies (mAbs) against complement regulatory proteins (CRPs:i.e.,CD46,CD55 and CD59) have been reported for adjuvant cancer therapy. In this study, we generated a recombinant 1E8 single-chain anti-CD59 antibody (scFv-Fc) and tested anti-cancer effect.by using complement dependent cytotoxicity (CDC). METHODS We isolated mRNA from 1E8 hybrid...

Journal: :Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie 2017
Christian Kellner Anna Otte Elisa Cappuzzello Katja Klausz Matthias Peipp

In the last two decades, monoclonal antibodies have revolutionized the therapy of cancer patients. Although antibody therapy has continuously been improved, still a significant number of patients do not benefit from antibody therapy. Therefore, rational optimization of the antibody molecule by Fc engineering represents a major area of translational research to further improve this potent therap...

2017
Cheng Luo Song Chen Na Xu Chi Wang Wen bo Sai Wei Zhao Ying chun Li Xiao jing Hu Hong Tian Xiang dong Gao Wen bing Yao

Pertuzumab is an antihuman HER2 antibody developed for HER2 positive breast cancer. Glycosylation profiles are always the important issue for antibody based therapy. Previous findings have suggested the impact of glycosylation profiles on the function of antibodies, like pharmacodynamics, antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). However, the r...

Journal: :Transplant immunology 2005
Oyedele A Adeyi Alin L Girnita Judy Howe Marilyn Marrari Yehia Awadalla Medhat Askar Joan Martell Adrian Zeevi Ron Shapiro Michael Nalesnik Parmjeet Randhawa Anthony J Demetris René J Duquesnoy

This study deals with HLA-mismatched kidney transplants that have been removed following rejection. Sera from 27 patients were screened for HLA-specific antibodies by direct complement-dependent lymphocytotoxicity with HLA-typed cell panels. Circulating donor-specific antibodies were detected in 3 cases (11%) before and in 26 cases (97%) after allograft nephrectomy. These findings demonstrate t...

Journal: :Molecular cancer therapeutics 2013
Sylvia Herter Frank Herting Olaf Mundigl Inja Waldhauer Tina Weinzierl Tanja Fauti Gunter Muth Doris Ziegler-Landesberger Erwin Van Puijenbroek Sabine Lang Minh Ngoc Duong Lina Reslan Christian A Gerdes Thomas Friess Ute Baer Helmut Burtscher Michael Weidner Charles Dumontet Pablo Umana Gerhard Niederfellner Marina Bacac Christian Klein

We report the first preclinical in vitro and in vivo comparison of GA101 (obinutuzumab), a novel glycoengineered type II CD20 monoclonal antibody, with rituximab and ofatumumab, the two currently approved type I CD20 antibodies. The three antibodies were compared in assays measuring direct cell death (AnnexinV/PI staining and time-lapse microscopy), complement-dependent cytotoxicity (CDC), anti...

2017
Yuan Mao Jun Wang Mingzhi Zhang Weifei Fan Qi Tang Siping Xiong Xiaojun Tang Juqing Xu Lin Wang Shu Yang Suyao Liu Li Xu Yan Chen Lin Xu Rong Yin Jin Zhu

Latent membrane protein 1 (LMP1), which is associated with the development of different types of Epstein-Barr virus (EBV) related lymphoma, has been suggested to be an important oncoprotein. In this study, a human anti-LMP1 IgG antibody (LMP1-IgG) was constructed and characterized by ELISA, western blotting (WB), affinity and immunohistochemistry (IHC) analyses. CCK-8, MTT, apoptosis assays, an...

Journal: :Nephrology Dialysis Transplantation 2023

Abstract Background and Aims Human Leukocyte antigen (HLA) sensitization in patients is a barrier for Kidney Transplantation (KT) access, highly-sensitized remain on the waiting list longer than other which results higher morbidity mortality. Desensitization may be an option to increase their access KT. All transplanted this context have negative Complement-Dependent Cytotoxicity crossmatch (CD...

2017
Juhan Lee Borae G. Park Hyang Sook Jeong Youn Hee Park Sinyoung Kim Beom Seok Kim Hye Jin Kim Kyu Ha Huh Hyeon Joo Jeong Yu Seun Kim

RATIONALE Human leukocyte antigen (HLA) is the major immunologic barrier in kidney transplantation (KT). Various desensitization protocols to overcome the HLA barrier have increased the opportunity for transplantation in sensitized patients. In addition, technological advances in solid-phase assays have permitted more comprehensive assessment of donor-specific antibodies. Although various desen...

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