The effects of cytidine 5'-diphosphocholine (CDP-choline) on neurologic deficits and cerebral glucose metabolism were studied in a rat model of transient cerebral ischemia. Cerebral ischemia was induced by occluding both common carotid arteries for 20 or 30 minutes 24 hours after the vertebral arteries were permanently occluded by electrocautery. CDP-choline was administered intraperitoneally t...

BACKGROUND CDP-choline is a key intermediate in the biosynthesis of phosphatidylcholine, which is an essential component of cellular membranes, and a cell signalling mediator. CDP-choline has been used for the treatment of cerebral ischaemia, showing beneficial effects. However, its potential benefit for the treatment of myocardial ischaemia has not been explored yet. AIM In the present work,...

The CCAAT-displacement protein (CDP) has been implicated in developmental and cell-type-specific regulation of many cellular and viral genes. We previously have shown that CDP represses mouse mammary tumor virus (MMTV) transcription in tissue culture cells. Since CDP-binding activity for the MMTV long terminal repeat declines during mammary development, we tested whether binding mutations could...

INTRODUCTION: Secondary lymphedema is a chronic and debilitating complication of breast cancer therapy affecting more than one in five breast cancer survivors.1 In this patient population, patient-reported outcomes may be more important in predicting long-term health-related quality of life (HRQoL) than clinician measured outcomes.2 Cost-effectiveness analysis can be used to compare different t...

Expression of human papillomavirus genes increases as the target cell, the keratinocyte, differentiates. CCAAT displacement protein (CDP) is a cellular protein which has been shown in other cell types to negatively regulate gene expression in undifferentiated cells but not in differentiated cells. We have previously shown that a 66-bp purine-thymidine-rich sequence (the 66-mer) binds CDP and ne...

1 ABSTRACT Accurate assessment of the stenosis severity is critical in patients with aortic stenosis (AS). The ambiguities and reduced sensitivities of the current diagnostic parameters can result in sub-optimal clinical decision making. In this preliminary study, we investigate the functional diagnostic parameter CDP (ratio of the transvalvular pressure drop to the proximal dynamic pressure) f...

The enzymatic system for the formation of @dine diphosphate 3,6dideoxyhexose from CDP-4-keto-6-deoxy-nglucose has been separated into three protein fractions. Two of these fractions, El and E3, participate in a TPNHrequiring reaction in which a new cytidine nucleotide intermediate is formed. Since this intermediate can be reduced chemically to yield 3,6-dideoxy-n-galactose (abequose) and 3,6-di...