Transient osteoporosis is a rare condition causing regional pain, immobility and functional compromise. The authors present the case of a pregnant lady with multiple sites of transient osteoporosis, including a stress fracture, successfully treated with intravenous pamidronate and a physical rehabilitation programme. The authors discuss the mechanisms for the syndrome and its overlap with compl...

Article first published online: 23 JUL 2013. This is the accepted version of the following article: Moule, P., Lewis, J. and McCabe, C. (2014) Designing and delivering an educational package to meet the needs of primary care health professionals in the diagnosis and management of those with complex regional pain syndrome. Musculoskeletal Care, 12 (2). pp. 114?117, which has been published in fi...

INTRODUCTION Memantine was discovered in 1968 and is used as a treatment for Alzheimer's disease. We evaluated the use of memantine to treat complex regional pain syndrome in this retrospective study. PATIENTS AND METHODS 56 patients with CRPS, who were treated with trial of memantine for at least two months with 40mg QHS from 2007 until 2009. RESULTS 34 females and 22 male patients. Age-46...

Chronic regional pain syndrome (CRPS) can be intractable to treat and patients sometimes suffer for many years. Therefore, new treatment strategies are needed to alleviate symptoms in CRPS patients. This case report describes a patient suffering from intractable CRPS type 1 for 13 years. Due to her swollen painful feet and left knee she is wheelchair-bound. The combination of palmitoylethanolam...

The aim of this prospective study was to assess the efficacy of shockwave (SW) therapy in the management of complex regional pain syndrome (CRPS). In this study, 30 patients (pts) who were affected by CRPS of the medial femoral condyle and unresponsive to previous standard physiotherapeutic and pharmacological treatment underwent 3 SW sessions at 72-h intervals, each consisting of 4000 shocks e...

Pediatric complex regional pain syndrome (P-CRPS) offers a unique model of chronic neuropathic pain as it either resolves spontaneously or through therapeutic interventions in most patients. Here we evaluated brain changes in well-characterized children and adolescents with P-CRPS by measuring resting state networks before and following a brief (median = 3 weeks) but intensive physical and psyc...

Barrie Fischer is Consultant Anaesthetist at the Alexandra Hospital, Redditch (Worcestershire Acute Hospitals NHS Trust), UK. He qualified from the University of Bristol and trained in Truro, Cambridge and Cardiff. His main interests are the role of regional anaesthesia in surgery and acute pain management. He is the representative of Great Britain and Ireland on the Board of the European Socie...

This is a review of current literature of noninvasive treatments for pediatric complex regional pain syndrome (CRPS). There are a variety of noninvasive approaches to the treatment of pain, but few pediatric-focused studies have been published in regard to CRPS. In comparison with adult CRPS, there is a greater need for behavioral approaches in children to enable coping with difficult symptoms....

Complex regional pain syndrome (CRPS) is a relatively common disabling disorder of unknown pathophysiology. CRPS is a variable symptom complex that probably results from multiple causes through different pathophysiological mechanisms. Changes in peripheral, central, somatosensory, autonomic, and motor processing, accompanied by pathological interactions of sympathetic and afferent systems, are ...

Complex regional pain syndrome (CRPS) is characterized by pain and disturbed blood flow, temperature regulation and motor control. Approximately 25% of cases develop fixed dystonia. The origin of this movement disorder is poorly understood, although recent insights suggest involvement of disturbed force feedback. Assessment of sensorimotor integration may provide insight into the pathophysiolog...