Purpose: With the introduction of combinatorial chemistry and high throughput screening, the properties of new chemical entities shifted towards higher molecular weight and increasing lipophilicity that results in decreasing aqueous solubility. It is not surprising that many drug candidates have poor water solubility since the initial selection of drug candidates are based on activity alone. Ot...

This study deals with the preparation and investigation of a nanoscale delivery system for the anticancer drug doxorubicin (DOX) using its complexation with polyanionic carbohydrate dextran sulfate (DS). Dynamic light scattering, SEM, and zeta potential determination were used to characterize nanocomplexes. DOX-DS complexation was studied in the presence of ethanol as a hydrogen-bond disrupting...

Natural lipophilic bioactives that possess human health benefits, such as coenzyme Q10 (CoQ10) and R-α-lipoic acid (RALA), often have undesirable characteristics that limit their use as nutraceuticals and cosmeceuticals. These bioactives are usually unstable against oxygen, ultraviolet light, low pH and heat. Furthermore, their watersolubility is low because of their hydrophobic nature or insta...

We examined complexes between cucurbit[6]uril and each of ortho-, meta-, and para-phenylenediamine using computational methods, Fourier transform ion cyclotron resonance mass spectrometry, and ion mobility spectrometry. These fundamental gas phase studies show that the lowest energy binding sites for ortho- and meta-phenylenediamine are on the exterior of cucurbit[6]uril, whereas para-phenylene...

During the past 15 years, coordination chemistry has rapidly developed toward multicomponent assemblies involving several ligands and metal ions, which are connected via intra- or intermolecular processes. The fascinating structural aspect of these complexation reactions has been early recognized for the design of sophisticated (supra)molecular architectures with novel topologies and functions,...

Ion-molecule complexation dynamics were studied with CH3SCN and Li(+) in acetonitrile by vibrationally probing the nitrile stretching vibration of CH3SCN. The nitrile stretching vibration of CH3SCN has a long lifetime (T1 = ∼90 ps) and its frequency is significantly blue-shifted when CH3SCN is bound with Li(+) ions to form a CH3SCNLi(+) complex in acetonitrile. Such spectral properties enable u...

Various chemical models of ion adsorption are presented and discussed. Chemical models, such as surface complexation models, provide a molecular description of anion adsorption reactions using an equilibrium approach. Two such models, the constant capacitance model and the triple layer model, are described in the present study. Characteristics common to all the surface complexation models are e...

Tracer studies in healthy volunteers using stable isotopes of ruthenium were performed with the objective of extending the limited knowledge about the biokinetics of the radionuclides of this element. Tracer solutions were prepared starting from metallic ruthenium powders enriched in either Ru or Ru (isotopic enrichment ca. 98%). Tracer administration was followed by the collection of blood and...

Objective: The present work describes complexation study of sulfonylurea based drug, glimepiride with divalent metal ions (Mg2+, Ca2+, Cu2+and Zn2+ Methods: The stoichiometry of resulting metal ion-glimepiride complexes were ascertained by molar conductance vs. mole ratio of glimepiride/metal ion plots, Job’s method of continuous variation and liquid chromatography-mass spectrometric analysis. ...

A high dosage of albendazole (ABZ) is required for treating systemic helminthe infections because of its low solubility. Aiming at increasing ABZ solubility, complexation with beta-cyclodextrin ( -CD) using aqueous and acetic acid solutions as ABZ solubilizer was studied. In aqueous -CD, complexation increased solubility 53.4 times, giving a complex equilibrium constant of 1266 L mol with a max...