PURPOSE To investigate the combined effect of olfactory ensheathing cell (OEC) transplantation and recombinant human glial cell line-derived neurotrophic factor (rhGDNF) intravitreal injection on optic nerve functional recovery following incomplete injury in adult rats. METHODS The optic nerves of adult rats were crushed by forceps and then GDNF was injected into vitreous cavity, OECs transpl...

BACKGROUND Neoadjuvant chemotherapy followed by surgery is the standard of care for UK patients with locally advanced resectable oesophageal carcinoma (OeC). However, not all patients benefit from multimodal treatment and there is a clinical need for biomarkers which can identify chemotherapy responders. This study investigated whether the proportion of tumour cells per tumour area (PoT) measur...

در این تحقیق از بهینه‌سازی تابع هدف طراحی آزمایشی تاگوچی برای یافتن شرایط بهینه فرایند قالبگیری تزریق به‌کمک آب برای دو پلیمر ABS و PP استفاده شده است. به منظور قالبگیری تزریقی نمونه‌‌ها، قالب لوله‌ای دو سر با حفره مواد اضافه و نازل تزریق آب طراحی و ساخته شد. با توجه به اینکه توابع هدف مختلفی در این فرایند مدنظر است، لذا از روش بهینه‌سازی تابع هدف با معیارهای چندگانه کلی (OEC)استفاده شد. نوع مش...

Automotive applications often experience conflicting-objective optimization problems focusing on performance parameters that are catered through precisely developed cost functions. Two such conflicting objectives which substantially affect the working of traction machine drive maximizing its speed and minimizing energy consumption. In case an electric vehicle (EV) powertrain, is bounded by batt...

Water oxidation, forming O(2) from water and sunlight, is a fundamental process for life on earth. In nature, the enzyme photosystem II (PSII) catalyzes this reaction. The oxygen evolving complex (OEC), the complex within PSII that catalyzes the actual formation of the O-O bond, contains four manganese atoms and one calcium atom connected by oxo bonds. Seven amino acid side chains in the struct...

Oxygen-oxygen bond formation and O2 generation occur from the S4 state of the oxygen-evolving complex (OEC). Several mechanistic possibilities have been proposed for water oxidation, depending on the formal oxidation state of the Mn atoms. All fall under two general classifications: the AB mechanism in which nucleophilic oxygen (base, B) attacks electrophilic oxygen (acid, A) of the Mn4Ca clust...

We examined the effect of muscle basal lamina (MBL) with neural stem cells (NSCs) and olfactory ensheathing cells (OECs) on spinal cord injury repair. Seventy-two Sprague-Dawley rats were subjected to spinal cord hemisection and divided into 6 groups. In blank control group (group A), the ends of the spinal cord hemisection model were flushed with physiological saline. In NSC transplantation gr...

Olfactory bulb tissue transplantation inhibits P2X2/3 receptor-mediated neuropathic pain. However, the olfactory bulb has a complex cellular composition, and the mechanism underlying the action of purified transplanted olfactory ensheathing cells (OECs) remains unclear. In the present study, we microencapsulated OECs in alginic acid, and transplanted free and microencapsulated OECs into the reg...