The elucidation of the basis of a rare inherited dis-development of hypertension, the biochemical abnormalities and the disturbances in cortisol meta-order is satisfying in itself, but particularly so if it leads to a greater understanding of normal physiology bolism.7 How then could cortisol, conventionally regarded as a glucocorticoid, act as a potent mineral-and other disease processes. Such...

A systematic measurement of ions and 2H/1H, 7Li/6Li, 11B/10B, 18O/ 16O, and 87Sr/86Sr isotopes in feed-waters, permeates, and brines from commercial reverse osmosis (RO) desalination plants in Israel (Ashkelon, Eilat, and Nitzana) and Cyprus (Larnaca) reveals distinctive geochemical and isotopic fingerprints of fresh water generated from desalination of seawater (SWRO) and brackish water (BWRO)...

The neutrino-nucleus reaction cross sections of 4He and 12C are evaluated using new shell model Hamiltonians. Branching ratios of various decay channels are calculated to evaluate the yields of Li, Be, and B produced through the ν-process in supernova explosions. The new cross sections enhance the yields of 7Li and 11B produced during the supernova explosion of a 16.2 M⊙ star model compared to ...

Murine IL-4 is a pleiotropic cytokine with undefined core functional region for eliciting downstream signaling. We used molecular modeling to predict the binding sites recognized by an anti-IL-4-neutralizing mAb (11B.11) and peptide phage display to delineate their makeup. The results of these approaches were confirmed by site-directed mutagenesis analysis. The results suggest that the amino ac...

Increasing evidence suggests that mineraloand glucocorticoids modulate cardiovascular homeostasis via the effects of circulating components generated within the adrenals but also through local synthesis. The aim of this study was to assess the existence of such a steroidogenic system in heart. Using the quantitative reverse transcriptase-polymerase chain reaction, the terminal enzymes of cortic...

A series of novel 11b-substituted 1,6,7,11b-tetrahydropyrimido[6,1-a]- isoquinoline-2,4-diones and 4-thioxo-1,3,4,6,7,11b-hexahydropyrimido[6,1-a]isoquinolin-2- ones were synthesized, utilizing two alternative strategies for ring closure of tetrahydroisoquinoline intermediates obtained from N-phenethyl enaminones.

A mutant, named 11B, hypersusceptible to aminoglycosides, tetracycline, and erythromycin was isolated after Tn501 insertion mutagenesis of Pseudomonas aeruginosa PAO1. Cloning and sequencing experiments showed that 11B was deficient in an, at that time, unknown active efflux system that contains homologs of MexAB. This locus also contained a putative regulatory gene, mexZ, transcribed divergent...

The two-state molecular orbital model of the one-dimensional phenyl-based semiconductors is applied to poly(para-phenylene vinylene). The energies of the low-lying excited states are calculated using the density matrix renormalization group method. Calculations of both the exciton size and the charge gap show that there are both 1B− u and 1 A + g excitonic levels below the band threshold. The e...