Computational prediction of protein subcellular locations in eukaryotes facilitates experimental design and proteome analysis. We provide a short review on recent development of computational tools and our experience in evaluating some of these tools. Classical secretomes can be relatively accurately predicted using computational tools to predict existence of a secretory signal peptide and to r...

Iowa State University 1.

Sep 26 Alex Mogilner, UC Davis Self-organizing microtubule asters in mitosis Mitosis is the process of segregation of chromosomes before cell division. This phenomenon is based on self-assembling molecular machine called mitotic spindle. The spindle consists of two asters made of microtubules, dynamic polymers that grow and shrink rapidly and repeatedly probing space and searching for the chrom...

The paper presents a new approach based on process calculi to systems modeling suitable for biological systems. The main characteristic of process calculi is a linguistic description level to define incrementally and compositionally executable models. The formalism is suitable to be exploited on the same system at different levels of abstractions connected through well defined formal rules. The...

At the request of the PLoS Computational Biology Editor-inChief, I agreed to write about computational biology in Brazil (see author information in Box 1). That meant describing: a) the history of the field in our country (short as the history of the field itself is short); b) the current state of the field in Brazil; c) the influence of computational biology–related technologies on the develop...

1 Laboratorio de Micologı́a y Fitopatologı́a, Departamento de Ciencias biológicas, Universidad de los Andes, Bogotá, Colombia, 2 Centro de Bioinformática-Instituto de Biotecnologı́a (IBUN), Universidad Nacional de Colombia, Bogotá, Colombia, 3 Grupo de Investigación en Bioinformática, Escuela de Ingenierı́a de Sistemas y Computación, Universidad del Valle, Cali, Colombia, 4 GEBIXCentro Colombiano d...

Computational biology is an interdisciplinary science bred from fields as disparate as mathematics, chemistry, statistics, physics, biology, and computer science. Although the exact definition of computational biology is far from being precise and unambiguous, it is a fact that hundreds of scientists around the world have been increasingly using skills from the above-mentioned fields to approac...

UNLABELLED Möbius has found numerous applications in computational biology to build and solve stochastic models of biological processes. It provides the user with a modeling workflow and several sophisticated features that are not available in the simulation tools commonly used by computational biologists. AVAILABILITY Möbius is free for academic users. It can be downloaded from www.mobius.ui...

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