(RP)-cAMPS is known to inhibit competitively the cAMP-induced activation of cAMP-dependent protein kinase (PKA). The molecular nature of this inhibition, however, is unknown. By monitoring the intrinsic tryptophan fluorescence of recombinant type I regulatory subunit of PKA under unfolding conditions, a free energy value (delta GDH2O) of 8.23 +/- 0.22 kcal/mol was calculated. The cAMP-free form...

The paper presents the post-war history of post-traumatic research conducted at the Department of Psychiatry of the Jagiellonian University and the analysis of the main research approaches and selected publications. The time after World War II passed in Poland in two directions: coping with the finished war trauma and simultaneously the experience of communist persecution trauma. First scientif...

The National Institute of Public Health was inaugurated on November 5, 1925. Since the very beginning it included four Departments: Department for the manufacture of sera and bacterial vaccines, Department for the manufacture of smallpox vaccine, Department for the Pasteur vaccination against rabies and Department for bacteriological diagnosis. All of these Departments closely cooperated. The m...

All anatomical departments of German universities used bodies of the executed and other victims of the National Socialist (NS) regime for their work. Many of these victims had been executed in prisons and were members of the German political opposition; others had perished in camps for prisoners of war or forced laborers and concentration camps, and were of various European and other descent. A...

qualities, especially when we find ourselves caught in the soulless, pitiless existence Rapoport describes. Is he unfair? Even he gave the MGB the names of friends and colleagues (p. 120), though throughout the book he tells us the probable dire effects of doing so. Yet he also cites instances of men forgiving colleagues for their betrayal, acknowledging that they could not help it (pp. 210-11)...

The impact of war on the population is vast, especially when it comes to those who were directly affected by war, among other things as concentration camp detainees. Because of the specific war experience of this population it is important to better understand the possible contribution of key socio-demographic variables, war traumatization and acute disturbances in mental health to their subjec...

Calorimetry is the basis of the science of nutrition, a statement I iirst saw as the title of a paper by the chief of the department of medicine at the Mayo Foundation (Wilder, 1959). Our science began when Lavoisier put a guinea pig into a calorimeter, measured the amount of ice melted and showed that this was quantitatively related to the amount of fixed air or carbon dioxide given off by the...

German psychiatrists proposed the extermination of mental patients before Hitler came to power. Then in Nazi Germany, organized psychiatry implemented involuntary eugenical sterilization and euthanasia, ultimately killing up to 100000 German mental patients. The six psychiatric euthanasia centers utilized medical professionals, fake death certificates, gas chambers disguised as showers, and the...

There is today a growing awareness both of the prevalence of torture involving a very large number of countries around the world and of the depth of the human suffering it leaves in its wake. Individual lives have been broken, the stability of families shattered, the psychic equilibrium of the children of torture victims disrupted. In the words of Simone Veil, former President of the European P...