Purpose This study aimed to assess and compare the pharmacokinetic (PK) and pharmacodynamic (PD) properties following a single subcutaneous injection of epoetin alfa (Eporon®) with those of the comparator (Eprex®) in healthy male subjects. Subjects and methods A randomized, double-blind, two-sequence, crossover study was conducted. Subjects were randomly assigned to receive a single dose, tha...

The goal of the present report is to compare several published methods of analyzing drug-drug interaction data. The compared methods are the curve-shift analysis, isobologram, combination index, and universal surface response analysis, and the comparison was based on analysis of published cytotoxicity data of combinations of two anti-folate agents. Major findings are as follows. The curve shift...

The effects of changed ionic environments on the canine taste responses to sugars were examined by recording the activity of the chorda tympani nerve. a) The responses to various sugars were greatly enhanced by the presence of salts having monovalent cations such as Na+, K+, choline+, or Tris+. The responses to sugars were suppressed by high concentrations of salts. (b) The presence of 100 mM N...

1. Characterization of P2X receptors on neurons of guinea-pig superior cervical ganglion (SCG) has been carried out using a whole-cell voltage-clamp technique. 2. Application of ATP and alpha,beta-methylene ATP (alphabeta-MeATP) produced fast activating inward currents, which desensitized slowly. The maximum response to alphabeta-MeATP was 36 +/- 23 % (range 0.1-100 %) of that evoked by ATP in ...

Five unrestrained male beagle dogs were given a continuous intravenous infusion for 28 days. First, 0.9% NaCl solution was infused for 7 days, then angiotensin II at 3 ng/kg per min for 14 days, and finally 0.9% NaCl for 7 days. We found that the blood pressure rose gradually in each dog, reaching a peak toward the end of the 14-day infusion of angiotensin IL When angiotensin infusion was stopp...

The 24-h area under the curve concentration (AUC24 h) is associated with better clinical and bacteriological response to vancomycin in patients methicillin-resistant Staphylococcus aureus who achieve target AUC24 h between 400 700 mg×h/L. Recent consensus recommends maintaining trough concentrations 15 20 mg/mL as a convenient target  reach an AUC/minimum inhibitory (MIC) ≥ 400. a...

In alpha1, beta2, and gamma2 subunits of the gamma-aminobutyric acid A (GABA(A)) receptor, a conserved lysine residue occupies the position in the middle of the predicted extracellular loop between the transmembrane M2 and M3 regions. In all three subunits, this residue was mutated to alanine. Whereas the mutation in alpha1 and beta2 subunits resulted each in about a sixfold shift of the concen...

0305-7364/0 * For corre bcgn.grignon. There is still disagreement about whether crop growth rate or soil nitrate concentration control nitrogen absorption by crops under ®eld conditions. The in ̄uence of these factors on the control of N uptake rate was examined in the absence of water stress, using data on dry matter production, above-ground nitrogen accumulation and soil nitrate concentration ...