PURPOSE To investigate the progression of cone dysfunction and degeneration in CNG channel subunit CNGB3 deficiency. METHODS Retinal structure and function in CNGB3(-/-) and wild-type (WT) mice were evaluated by electroretinography (ERG), lectin cytochemistry, and correlative Western blot analysis of cone-specific proteins. Cone and rod terminal integrity was assessed by electron microscopy a...

PURPOSE To elucidate the antigen recognized by monoclonal antibody (mAb) 7G6, a widely used cone-specific marker. METHODS 7G6 immunocytochemistry was performed on sections of human, primate, and bovine retina. The antigen was immunoprecipitated from human retinal lysates and purified with protein G. Edman degradation and liquid chromatography of tryptic peptides combined with tandem mass spec...

To study the L- and M-cone pathways and their interactions in patients with cone and cone-rod dystrophies, ERG responses were measured to stimuli which modulated exclusively the L- or the M-cones, or the two simultaneously. The L- and M-cone driven ERG amplitudes were considerably reduced in the patients. The mean phases of the L-cone driven ERGs in the patients lagged those of normals signific...

Cone electroretinograms (ERGs) in response to different color flashes were examined using a Ganzfeld stimulus in 19 eyes after successful retinal detachment surgery. In the operated eyes, the short wavelength sensitive (S-) cone b-wave was reduced more than the mixed long (L-) and middle (M-) wavelength sensitive cone b-waves. The ratio of the S-cone ERG b-wave amplitude between operated eyes a...

Flicker modulation sensitivity measurements made on high intensity orange steady backgrounds indicate that signals from short-wavelength sensitive cones (S-cones) have access to two pathways. At low S-cone adaptation levels the frequency response falls quickly with increasing frequency, but at higher adaptation levels it extends to much higher frequencies. At these higher S-cone adaptation leve...

In this paper we prove an analogue of Banach and Kannan fixed point theorems by generalizing the Lipschitz constat $k$, in generalized Lipschitz mapping on cone metric space over Banach algebra, which are answers for the open problems proposed by Sastry et al, [K. P. R. Sastry, G. A. Naidu, T. Bakeshie, Fixed point theorems in cone metric spaces with Banach algebra cones, Int. J. of Math. Sci. ...

Cone-valued lower semicontinuous maps are used to generalize Cristi-Kirik’s fixed point theorem to Cone metric spaces. The cone under consideration is assumed to be strongly minihedral and normal. First we prove such a type of fixed point theorem in compact cone metric spaces and then generalize to complete cone metric spaces. Some more general results are also obtained in quasicone metric spaces.