Correct wiring is crucial to the proper functioning of the nervous system. Key signals guiding growth cones, the motile tips of developing axons, to their targets are molecular gradients. The receptors on the membrane of the growth cone bind stochastically with guidance molecules in the environment, giving an estimate of the direction of the gradient. The growth cone then executes biased random...

We measured changes to cone photoreceptors in patients with early age-related macular degeneration. The data of 53 patients were compared with normative data for color matching measurements of long- and middle-wavelength-sensitive cones in the central macula. A four-parameter model quantified cone photopigment optical density and kinetics. Cone photopigment optical density was on average less f...

M-theory effects prevent five-dimensional domain-wall and black-hole solutions from developing curvature singularities. While so far this analysis was performed for particular models, we now present a model-independent proof that these solutions do not have naked singularities as long as the Kähler moduli take values inside the extended Kähler cone. As a by-product we obtain information on the ...

PURPOSE Human and swine retinas have morphological and functional similarities. In the absence of primate models, the swine is an attractive model to study retinal function and disease, with its cone-rich visual streak, our ability to manipulate their genome, and the differences in susceptibility of rod and cone photoreceptors to disease. We characterized the normal development of cone function...

Some types of biomass stoves, such as charcoal stoves, tend to be difficult to light due to poor initial draft and sensitivity to ambient wind. Decreasing the time necessary to light such stoves could increase user acceptance and convenience and decrease the user’s exposure to harmful emissions, as ignition is one of the smokiest portions of a cooking fire and may require close tending attentio...

The loss of cone photoreceptors that mediate daylight vision represents a leading cause of blindness, for which cell replacement by transplantation offers a promising treatment strategy. Here, we characterize cone differentiation in retinas derived from mouse embryonic stem cells (mESCs). Similar to in vivo development, a temporal pattern of progenitor marker expression is followed by the diffe...

We present the quantization of the Liouville model defined in light-cone coordinates in (1,1) signature space. We take advantage of the representation of the Liouville field by the free field of the Backlünd transformation and adapt the approch by Braaten, Curtright and Thorn [1] . Quantum operators of the Liouville field ∂+φ, ∂−φ, e , e are constructed consistently in terms of the free field. ...

Cone crushers are used in the aggregates and mining industries to crush rock material. The pressure on cone crusher liners is the key factor that influences the hydraulic pressure, power draw and liner wear. In order to dynamically analyze and calculate cone crusher performance along with liner wear, a series of experiments are performed to obtain the crushed rock material samples from a crushi...

To study the L- and M-cone pathways and their interactions in patients with Best's macular dystrophy (BMD), ERG response thresholds were measured to stimuli which modulated exclusively the L- or the M-cones, or both in various combinations. The ERG threshold data could be described with a vector addition model. Compared with normals, BMD patients showed generally larger amplitudes of the L-cone...

The original formulation of the MRS–Lade model, with non–associated flow rule on the meridian plane in the cone region, has a corner. In order to reduce the computational effort of corner solution algorithms, a modified plastic flow potential for the cone part is found in the literature. This modification may have a non–admissible flip over of the flow vector in the cone–cap intersection if the...