currently, hematopoietic stem cell transplantation (hsct) is the only curative option for patients with beta-thalassemia major, but liver iron overload in these patients will not decrease and hepatic fibrosis may still progress despite successful hsct. liver biopsy samples were taken from 14 patients (out of 25 patients) who underwent hsct. all patients met three criteria: negative hcv antibody...

Sixty five patients (20 children and 45 adults of both sexes) having hepatomegaly were subjected to serum copper, hepatic copper and hepatic cuproprotein analysis from October 1982 through September 1983. Higher levels of serum copper were encountered in 17/20 children suffering from Indian Childhood Cirrhosis (ICC), values ranging from 151 ug/dl to 350 ug/dl. Hypercupremia was also detected in...

This paper describes a case of Caroli's disease in a female patient aged 32, who complained of nonspecific abdominal pain without cholesthasis or cholangitis. Liver resonance shows segment saccular dilations closely connected to intrahepatic biliary ducts, that differ from the Caroli's syndrome, which is more common and consists of multiple intrahepatic cystic dilatations, associated to congeni...

Intrahepatic biliary dilatation or Caroli's disease is a rare clinical entity of unknown etiology. It consists of dilatation of intrahepatic biliary ducts which communicate with normal common bile duct system. It may manifest at any age but usual age of presentation is late childhood or early adult life. The clinical features of disease includes recurrent abdominal pain associated with fever, h...

Short term histological liver changes were studied in 13 patients with congenital biliary atresia, who showed good bile drainage after radical operation. Biopsies obtained at the time of the corrective surgery and at the second operation to convert from external total to partial bile drainage (undertaken once the bilirubin concentration was less than 30.8 mumol/l) were compared. A significant c...